H
Holger Doege
Researcher at RWTH Aachen University
Publications - 19
Citations - 2570
Holger Doege is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Fatty acid & Glucose transporter. The author has an hindex of 16, co-authored 19 publications receiving 2358 citations. Previous affiliations of Holger Doege include Hebrew University of Jerusalem & Palo Alto Medical Foundation.
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Journal ArticleDOI
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators
HG Joost,Graeme I. Bell,James D. Best,Morris J. Birnbaum,Maureen J. Charron,Yuan-Tsong Chen,Holger Doege,David E. James,Harvey F. Lodish,Kelle H. Moley,Jeffrey F. Moley,Mike Mueckler,Suzanne Rogers,Annette Schürmann,Susumu Seino,Bernard Thorens +15 more
TL;DR: The recent identification of several additional members of the family of sugar transport facilitators (gene symbol SLC2A, protein symbol GLUT) has created a heterogeneous and, in part, confusing nomenclature.
Journal ArticleDOI
FATP1 Is an Insulin-Sensitive Fatty Acid Transporter Involved in Diet-Induced Obesity
Qiwei Wu,Angelica M. Ortegon,Bernice Tsang,Holger Doege,Kenneth R. Feingold,Andreas Stahl,Andreas Stahl +6 more
TL;DR: This is the first in vivo evidence that insulin can regulate the uptake of LCFA by tissues via FATP1 activation and that FATPs determine the tissue distribution of dietary lipids.
Journal ArticleDOI
GLUT8, a Novel Member of the Sugar Transport Facilitator Family with Glucose Transport Activity
TL;DR: It is concluded that GLUT8 is a sugar transport facilitator with glucose transport activity and a hormonally regulated testicular function.
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Targeted Deletion of FATP5 Reveals Multiple Functions in Liver Metabolism: Alterations in Hepatic Lipid Homeostasis
Holger Doege,Rebecca Baillie,Angelica M. Ortegon,Bernice Tsang,Qiwei Wu,Sandhya Punreddy,David Hirsch,Nicki Watson,Ruth E. Gimeno,Andreas Stahl,Andreas Stahl +10 more
TL;DR: The hypothesis that efficient hepatocellular uptake of LCFAs, and thus liver lipid homeostasis in general, is largely a protein-mediated process requiring FATP5 is supported.
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Protein-Mediated Fatty Acid Uptake: Novel Insights from In Vivo Models
TL;DR: Long-chain fatty acids are both important metabolites as well as signaling molecules and key mediators of cellular fatty acid uptake and recent transgenic and knockout animal models have provided new insights into their contribution to energy homeostasis and to pathological processes, including obesity and insulin desensitization.