H
Holland S. Cordum
Researcher at Washington University in St. Louis
Publications - 6
Citations - 4058
Holland S. Cordum is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Y chromosome & Helicobacter pylori. The author has an hindex of 5, co-authored 6 publications receiving 3859 citations.
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Journal ArticleDOI
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Helen Skaletsky,Tomoko Kuroda-Kawaguchi,Patrick Minx,Holland S. Cordum,LaDeana W. Hillier,Laura G. Brown,Sjoerd Repping,Tatyana Pyntikova,Johar Ali,Tamberlyn Bieri,Asif T. Chinwalla,Andrew Delehaunty,Kim D. Delehaunty,Hui Du,Ginger A. Fewell,Lucinda Fulton,Robert S. Fulton,Tina Graves,Shunfang Hou,Philip Latrielle,Shawn Leonard,Elaine R. Mardis,Rachel Maupin,John Douglas Mcpherson,Tracie L. Miner,William E. Nash,Christine Nguyen,Philip Ozersky,Kymberlie H. Pepin,Susan M. Rock,Tracy Rohlfing,Kelsi Scott,Brian Schultz,Cindy Strong,Aye Mon Tin-Wollam,Shiaw-Pyng Yang,Robert H. Waterston,Richard K. Wilson,Steve Rozen,David C. Page +39 more
TL;DR: The male-specific region of the Y chromosome, the MSY, differentiates the sexes and comprises 95% of the chromosome's length, and is a mosaic of heterochromatic sequences and three classes of euchromatics sequences: X-transposed, X-degenerate and ampliconic.
Journal ArticleDOI
The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men.
Tomoko Kuroda-Kawaguchi,Helen Skaletsky,Helen Skaletsky,Laura G. Brown,Laura G. Brown,Patrick Minx,Holland S. Cordum,Robert H. Waterston,Richard K. Wilson,Sherman J. Silber,Robert D. Oates,Steve Rozen,Steve Rozen,David C. Page,David C. Page +14 more
TL;DR: The complete nucleotide sequence of AZFc was determined by identifying and distinguishing between near-identical amplicons (massive repeat units) using an iterative mapping–sequencing process.
Journal ArticleDOI
Abundant gene conversion between arms of palindromes in human and ape Y chromosomes
Steve Rozen,Helen Skaletsky,Janet D. Marszalek,Patrick Minx,Holland S. Cordum,Robert H. Waterston,Richard K. Wilson,David C. Page +7 more
TL;DR: It is concluded that during recent evolution, an average of approximately 600 nucleotides per newborn male have undergone Y–Y gene conversion, which has had an important role in the evolution of multi-copy testis gene families in the MSY.
Journal ArticleDOI
Evolution of symbiotic bacteria in the distal human intestine.
Jian Xu,Michael A. Mahowald,Ruth E. Ley,Catherine A. Lozupone,Micah Hamady,Eric C. Martens,Bernard Henrissat,Bernard Henrissat,Pedro M. Coutinho,Pedro M. Coutinho,Patrick Minx,P. Latreille,Holland S. Cordum,Andrew Van Brunt,Kyung-Ae Kim,Robert S. Fulton,Lucinda Fulton,Sandra W. Clifton,Richard K. Wilson,Robin D. Knight,Jeffrey I. Gordon +20 more
TL;DR: In this article, the authors examined how the intestinal environment affects microbial genome evolution and found that lateral gene transfer, mobile elements, and gene amplification have played important roles in affecting the ability of gut-dwelling Bacteroidetes to vary their cell surface, sense their environment, and harvest nutrient resources present in the distal intestine.
Journal ArticleDOI
The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: Evolution during disease progression
Jung D. Oh,Helene Kling-Bäckhed,Marios Giannakis,Jian Xu,Robert S. Fulton,Lucinda Fulton,Holland S. Cordum,Chunyan Wang,Glendoria Elliott,Jennifer Edwards,Elaine R. Mardis,Lars Engstrand,Jeffrey I. Gordon +12 more
TL;DR: The results reveal a shared gene signature among ChAG strains, as well as genes that may have been lost or gained during progression to adenocarcinoma, and indicates that genes encoding components of metal uptake and utilization pathways, outer membrane proteins, and virulence factors are among those associated with H. pylori's adaptation to ChAG.