M
Marios Giannakis
Researcher at Harvard University
Publications - 137
Citations - 8774
Marios Giannakis is an academic researcher from Harvard University. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 32, co-authored 99 publications receiving 5649 citations. Previous affiliations of Marios Giannakis include Broad Institute & Washington University in St. Louis.
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Journal ArticleDOI
Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma
Diana Miao,Diana Miao,Claire A. Margolis,Claire A. Margolis,Wenhua Gao,Martin H. Voss,Martin H. Voss,Wei Li,Dylan J. Martini,Craig Norton,Dominick Bossé,Stephanie M. Wankowicz,Stephanie M. Wankowicz,Dana Cullen,Christine Horak,Megan Wind-Rotolo,Adam Tracy,Marios Giannakis,Marios Giannakis,F.S. Hodi,Charles G. Drake,Mark W. Ball,Mohamad E. Allaf,Alexandra Snyder,Matthew D. Hellmann,Matthew D. Hellmann,Thai H. Ho,Robert J. Motzer,Robert J. Motzer,Sabina Signoretti,William G. Kaelin,William G. Kaelin,Toni K. Choueiri,Eliezer M. Van Allen,Eliezer M. Van Allen +34 more
TL;DR: Clinical benefit was associated with loss-of-function mutations in the PBRM1 gene, which encodes a subunit of the PBAF switch-sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, and may alter global tumor-cell expression profiles to influence responsiveness to immune checkpoint therapy.
Journal ArticleDOI
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma
Marios Giannakis,Marios Giannakis,Marios Giannakis,Xinmeng Jasmine Mu,Xinmeng Jasmine Mu,Xinmeng Jasmine Mu,Sachet A. Shukla,Sachet A. Shukla,Zhi Rong Qian,Ofir Cohen,Ofir Cohen,Reiko Nishihara,Samira Bahl,Yin Cao,Ali Amin-Mansour,Ali Amin-Mansour,Mai Yamauchi,Yasutaka Sukawa,Chip Stewart,Mara Rosenberg,Kosuke Mima,Kentaro Inamura,Katsuhiko Nosho,Jonathan A. Nowak,Michael S. Lawrence,Edward Giovannucci,Edward Giovannucci,Andrew T. Chan,Andrew T. Chan,Kimmie Ng,Kimmie Ng,Jeffrey A. Meyerhardt,Jeffrey A. Meyerhardt,Eliezer M. Van Allen,Eliezer M. Van Allen,Eliezer M. Van Allen,Gad Getz,Gad Getz,Stacey Gabriel,Eric S. Lander,Eric S. Lander,Eric S. Lander,Catherine J. Wu,Catherine J. Wu,Catherine J. Wu,Charles S. Fuchs,Charles S. Fuchs,Shuji Ogino,Shuji Ogino,Levi A. Garraway,Levi A. Garraway,Levi A. Garraway +51 more
TL;DR: It was found that higher neoantigen load was positively associated with overall lymphocytic infiltration, tumor-infiltrating lymphocytes, memory T cells, and CRC-specific survival and positive selection of mutations in HLA genes and other components of the antigen-processing machinery in TIL-rich tumors.
Journal ArticleDOI
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
Kosuke Mima,Reiko Nishihara,Zhi Rong Qian,Yin Cao,Yasutaka Sukawa,Jonathan A. Nowak,Juhong Yang,Juhong Yang,Ruoxu Dou,Yohei Masugi,Mingyang Song,Aleksandar Kostic,Aleksandar Kostic,Marios Giannakis,Marios Giannakis,Marios Giannakis,Susan Bullman,Susan Bullman,Danny A. Milner,Danny A. Milner,Hideo Baba,Edward Giovannucci,Edward Giovannucci,Levi A. Garraway,Levi A. Garraway,Levi A. Garraway,Gordon J. Freeman,Gordon J. Freeman,Glenn Dranoff,Glenn Dranoff,Wendy S. Garrett,Wendy S. Garrett,Curtis Huttenhower,Curtis Huttenhower,Matthew Meyerson,Matthew Meyerson,Matthew Meyerson,Jeffrey A. Meyerhardt,Andrew T. Chan,Andrew T. Chan,Charles S. Fuchs,Charles S. Fuchs,Shuji Ogino,Shuji Ogino +43 more
TL;DR: The amount of F. nucleatum DNA in colorectal cancer tissue is associated with shorter survival, and may potentially serve as a prognostic biomarker, which may have implications in developing cancer prevention and treatment strategies through targeting GI microflora by diet, probiotics and antibiotics.
Journal ArticleDOI
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.
Cayetano Pleguezuelos-Manzano,Jens Puschhof,Axel Rosendahl Huber,Arne Van Hoeck,Henry M. Wood,Jason Nomburg,Jason Nomburg,Carino Gurjao,Carino Gurjao,Freek Manders,Guillaume Dalmasso,Paul B. Stege,Fernanda L. Paganelli,Maarten H. Geurts,Joep Beumer,Tomohiro Mizutani,Yi Miao,Reinier van der Linden,Stefan van der Elst,K. Christopher Garcia,Janetta Top,Rob J. L. Willems,Marios Giannakis,Marios Giannakis,Richard Bonnet,Phil Quirke,Matthew Meyerson,Edwin Cuppen,Ruben van Boxtel,Hans Clevers +29 more
TL;DR: A distinct mutational signature in colorectal cancer is described and it is implied that the underlying mutational process results directly from past exposure to bacteria carrying the colibactin-producing pks pathogenicity island.
Journal ArticleDOI
Fusobacterium nucleatum and T Cells in Colorectal Carcinoma.
Kosuke Mima,Yasutaka Sukawa,Reiko Nishihara,Zhi Rong Qian,Mai Yamauchi,Kentaro Inamura,Kentaro Inamura,Sun A. Kim,Atsuhiro Masuda,Jonathan A. Nowak,Katsuhiko Nosho,Aleksandar Kostic,Aleksandar Kostic,Marios Giannakis,Marios Giannakis,Hideo Watanabe,Hideo Watanabe,Susan Bullman,Susan Bullman,Danny A. Milner,Danny A. Milner,Curtis C. Harris,Edward Giovannucci,Levi A. Garraway,Levi A. Garraway,Gordon J. Freeman,Gordon J. Freeman,Glenn Dranoff,Glenn Dranoff,Andrew T. Chan,Andrew T. Chan,Wendy S. Garrett,Wendy S. Garrett,Curtis Huttenhower,Curtis Huttenhower,Charles S. Fuchs,Charles S. Fuchs,Shuji Ogino,Shuji Ogino +38 more
TL;DR: The human population data may provide an impetus for further investigations on potential interactive roles of Fusobacterium and host immunity in colon carcinogenesis, and the amount of tissue F nucleatum is inversely associated with CD3+ T-cell density in colorectal carcinoma tissue.