H
Holly Kuzmiak
Researcher at University of Rochester
Publications - 4
Citations - 369
Holly Kuzmiak is an academic researcher from University of Rochester. The author has contributed to research in topics: Gene & Transcriptionally silent chromatin. The author has an hindex of 4, co-authored 4 publications receiving 353 citations.
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Journal ArticleDOI
Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges
Holly Kuzmiak,Lynne E. Maquat +1 more
TL;DR: How to determine which PTCs elicit NMD is reviewed, what is currently known about the mechanism of NMD, and additional information that is pertinent to establishing therapies for PTC-associated diseases are reviewed.
Journal ArticleDOI
Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction.
Mohammed Sebaihia,Andrew Preston,Duncan J. Maskell,Holly Kuzmiak,Terry D. Connell,Natalie D. King,Paul E. Orndorff,David M. Miyamoto,Nicholas R. Thomson,David Harris,Arlette Goble,Angela Lord,Lee Murphy,Michael A. Quail,Simon Rutter,R. Squares,S. Squares,John Woodward,Julian Parkhill,Larissa K. Temple +19 more
TL;DR: The presence or absence of previously reported virulence factors from B. avium was confirmed, and the genetic bases for growth characteristics were elucidated, and a number of putative iron-regulated outer membrane proteins were predicted from the sequence and regulation was confirmed experimentally for five of these.
Journal ArticleDOI
Saccharomyces cerevisiae Linker Histone Hho1p Functionally Interacts with Core Histone H4 and Negatively Regulates the Establishment of Transcriptionally Silent Chromatin
TL;DR: Deletion of HHO1 (hho1Δ) suppresses the defect in transcriptional silencing caused by a mutation in the globular domain of histone H4 and provides evidence that Hho1p hinders the de novo establishment of silent Chromatin but does not affect the stability of preexistent silent chromatin.
Journal ArticleDOI
Saccharomyces cerevisiae Esc2p Interacts with Sir2p through a Small Ubiquitin-like Modifier (SUMO)-binding Motif and Regulates Transcriptionally Silent Chromatin in a Locus-dependent Manner
TL;DR: It is demonstrated here that ESC2 differentially regulates silent chromatin at telomeric, rDNA, and HM loci, and a putative SUMO-binding motif that is necessary and sufficient for interacting with Sir2p and SUMO and is required for the function of Esc2p in transcriptional silencing is identified.