H
Homayoun Vaziri
Researcher at Ontario Institute for Cancer Research
Publications - 12
Citations - 6198
Homayoun Vaziri is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: Telomere & Telomerase. The author has an hindex of 10, co-authored 12 publications receiving 6078 citations. Previous affiliations of Homayoun Vaziri include McMaster University & Geron Corporation.
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Journal ArticleDOI
Telomere length predicts replicative capacity of human fibroblasts.
Richard C. Allsopp,Homayoun Vaziri,Christopher Patterson,S Goldstein,Edward V. Younglai,A B Futcher,Carol W. Greider,Calvin B. Harley +7 more
TL;DR: Telomere length is a biomarker of somatic cell aging in humans and is consistent with a causal role for telomere loss in this process, and fibroblasts from Hutchinson-Gilford progeria donors had short telomeres, consistent with their reduced division potential in vitro.
Journal ArticleDOI
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age
Homayoun Vaziri,Wieslawa H. Dragowska,Richard C. Allsopp,Terry E. Thomas,Calvin B. Harley,Peter M. Lansdorp +5 more
TL;DR: It is shown that candidate human stem cells with a CD34+CD38lo phenotype that were purified from adult bone marrow have shorter telomeres than cells from fetal liver or umbilical cord blood and that cells produced in cytokine-supplemented cultures of purified precursor cells show a proliferation-associated loss of telomeric DNA.
Journal ArticleDOI
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
Homayoun Vaziri,Samuel Benchimol +1 more
TL;DR: Results show that retroviral-mediated expression of hTERT resulted in functional telomerase activity in normal aging human cells, indicating that telomere length is one factor that can determine the replicative life span of human cells.
Journal ArticleDOI
The telomere hypothesis of cellular aging.
Journal ArticleDOI
Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow.
Choy-Pik Chiu,Wieslawa H. Dragowska,Nam Woo Kim,Homayoun Vaziri,Jane Yui,Terry E. Thomas,Calvin B. Harley,Peter M. Lansdorp +7 more
TL;DR: Examination of subpopulations of hematopoietic cells from adult human bone marrow using a sensitive polymerase chain reaction‐based telomeric repeat amplification protocol suggests that telomerase is expressed at a basal level in all hematopolietic cell populations examined, is induced in a primitive subset ofhematopOietic progenitor cells and is downregulated upon further proliferation and differentiation of these cells.