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Christopher M. Counter
Researcher at Duke University
Publications - 128
Citations - 21997
Christopher M. Counter is an academic researcher from Duke University. The author has contributed to research in topics: Telomere & Telomerase reverse transcriptase. The author has an hindex of 53, co-authored 124 publications receiving 20736 citations. Previous affiliations of Christopher M. Counter include McMaster University & Geron Corporation.
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Journal ArticleDOI
Creation of human tumour cells with defined genetic elements
William C. Hahn,William C. Hahn,Christopher M. Counter,Ante S. Lundberg,Ante S. Lundberg,Roderick L. Beijersbergen,Mary W. Brooks,Robert A. Weinberg +7 more
TL;DR: It is shown that the ectopic expression of the telomerase catalytic subunit (hTERT) in combination with two oncogenes results in direct tumorigenic conversion of normal human epithelial and fibroblast cells.
Telomere shortening associated withchromosome instability isarrested inimmortal cells whichexpress telomerase activity
Christopher M. Counter,Ariel A. Avilion,Catherine E. LeFeuvrel,Carol W. Greider,Calvin B. Harley,A. Steitz +5 more
TL;DR: The results suggest that chromosomes with short (TTAGGG)n tracts are recombinogenic, critically shortened telomeres may be incompatible with cell proliferation and stabilization of telomere length by telomerase may be required for immortalization.
Journal ArticleDOI
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Christopher M. Counter,A.A. Avilion,C.E. LeFeuvre,N.G. Stewart,Carol W. Greider,Calvin B. Harley,Silvia Bacchetti +6 more
TL;DR: In this article, the authors measured telomere length, telomerase activity and chromosome rearrangements in human cells before and after transformation with SV40 or Ad5 and found that telomeres shortened by approximately 65 bp/generation during the lifespan of the cultures.
Journal ArticleDOI
hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization
Matthew Meyerson,Christopher M. Counter,Elinor Ng Eaton,Leif W. Ellisen,Philipp Steiner,Stephanie Dickinson Caddle,Liuda Ziaugra,Roderick L. Beijersbergen,Michael J. Davidoff,Qingyun Liu,Silvia Bacchetti,Daniel A. Haber,Robert A. Weinberg +12 more
TL;DR: The cloning of a human gene, hEST2, that shares significant sequence similarity with the telomerase catalytic subunit genes of lower eukaryotes is reported, suggesting that the induction of hEST 2 mRNA expression is required for the telomersase activation that occurs during cellular immortalization and tumor progression.
Journal ArticleDOI
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
Elizabeth S. Yeh,Melissa Cunningham,Hugh Arnold,Dawn Chasse,Teresa Monteith,Giovanni Ivaldi,William C. Hahn,P. Todd Stukenberg,Shirish Shenolikar,Takafumi Uchida,Christopher M. Counter,Joseph R. Nevins,Anthony R. Means,Rosalie C. Sears +13 more
TL;DR: It is shown that Ser 62 is dephosphorylated by protein phosphatase 2A (PP2A) before ubiquitination of c-Myc, and that PP2A activity is regulated by the Pin1 prolyl isomerase, resulting in c- myc stabilization.