H
Hongzhou Gu
Researcher at Fudan University
Publications - 30
Citations - 2175
Hongzhou Gu is an academic researcher from Fudan University. The author has contributed to research in topics: DNA & DNA nanotechnology. The author has an hindex of 12, co-authored 24 publications receiving 1591 citations. Previous affiliations of Hongzhou Gu include Yale University & Fudan University Shanghai Medical College.
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A proximity-based programmable DNA nanoscale assembly line
TL;DR: It is demonstrated that a nanoscale assembly line can be realized by the judicious combination of three known DNA-based modules: a DNA origami tile that provides a framework and track for the assembly process, cassettes containing three independently controlled two-state DNA machines that serve as programmable cargo-donating devices and a DNA walker that can move on the track from device to device and collect cargo.
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DNA Nanotechnology-Enabled Drug Delivery Systems
TL;DR: The origin of DNA nanotechnology is reviewed, followed by summarizing state-of-the-art strategies for the construction of DNAnanostructures and drug payloads delivered by DNA nanovehicles and challenges and opportunities for DNA nanostructure-based drug delivery.
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Concept and Development of Framework Nucleic Acids.
TL;DR: This Perspective highlights state-of-the-art design and construction, of precisely assembled FNAs, and outlines the challenges and opportunities for exploiting the structural potential of FNAs for translational applications.
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Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate.
TL;DR: A dynamic form of patterning is demonstrated in which a pattern component is captured between two independently programmed DNA devices and this capture system can lead to dynamic control either on patterns or on programmed elements.
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Small, highly active DNAs that hydrolyze DNA.
Hongzhou Gu,Kazuhiro Furukawa,Zasha Weinberg,Zasha Weinberg,Daniel F. Berenson,Ronald R. Breaker,Ronald R. Breaker +6 more
TL;DR: Natural DNA sequences conforming to the class I consensus sequence and structure were found that undergo hydrolysis under selection conditions, which demonstrates that the inherent structure of certain DNA regions might promote catalytic reactions, leading to genomic instability.