H
Honyin Chiu
Researcher at University of California, Irvine
Publications - 11
Citations - 1597
Honyin Chiu is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Immunoglobulin class switching & PI3K/AKT/mTOR pathway. The author has an hindex of 5, co-authored 9 publications receiving 988 citations. Previous affiliations of Honyin Chiu include Benaroya Research Institute.
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Journal ArticleDOI
The PI3K pathway in human disease
David A. Fruman,Honyin Chiu,Benjamin D. Hopkins,Shubha Bagrodia,Lewis C. Cantley,Robert T. Abraham +5 more
TL;DR: A perspective on the roles of class I PI3Ks in the regulation of cellular metabolism and in immune system functions is provided, two topics closely intertwined with cancer biology.
Journal ArticleDOI
mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.
Jose J. Limon,Lomon So,Stefan Jellbauer,Honyin Chiu,Juana Corado,Stephen M. Sykes,Manuela Raffatellu,David A. Fruman +7 more
TL;DR: It is found that a new class of ATP-competitive mTOR kinase inhibitors (TOR-KIs) can augment antibody class switching at concentrations that partially inhibit mTOR activity, and opposing roles for mTORC1 and m TORC2 in B-cell differentiation are identified and mechanisms of mTOR signaling in B cells are uncovers.
Journal ArticleDOI
The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes.
Honyin Chiu,Leandra V. Jackson,Kwon Ik Oh,Kwon Ik Oh,Annie Mai,Ze'ev Ronai,Davide Ruggero,David A. Fruman +7 more
TL;DR: A previously undescribed role for mTORC1 and the eif4E-binding proteins/eIF4E axis in activation-induced cytidine deaminase protein expression and Ab class switching in mouse B cells is uncovered, suggesting that cap-dependent translation regulates key steps in B cell differentiation.
Journal ArticleDOI
The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation
Honyin Chiu,Sharmila Mallya,Phuongthao Nguyen,Annie Mai,Leandra V. Jackson,David G. Winkler,Jonathan P. DiNitto,Erin Brophy,Karen McGovern,Jeffery L. Kutok,David A. Fruman +10 more
TL;DR: Findings show that p110δ is the dominant isoform mediating B cell responses and establish that IPI-3063 is a highly potent molecule useful for studying p 110δ function in immune cells.
Journal ArticleDOI
Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax.
Lee-or Herzog,Beth Walters,Roberta Buono,J. Scott Lee,J. Scott Lee,Sharmila Mallya,Amos Fung,Honyin Chiu,Honyin Chiu,Nancy Nguyen,Boyang Li,Anthony B. Pinkerton,Michael R. Jackson,Robert J. Schneider,Ze'ev Ronai,David A. Fruman +15 more
TL;DR: The data highlight a novel combination for treatment of aggressive lymphomas, and establishes its efficacy and selectivity using preclinical models.