H
Horacio Soto
Researcher at University of California, Los Angeles
Publications - 37
Citations - 4076
Horacio Soto is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Glioma & Immunotherapy. The author has an hindex of 21, co-authored 36 publications receiving 3546 citations.
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Journal ArticleDOI
Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma
Rameen Beroukhim,Gad Getz,Leia Nghiemphu,Jordi Barretina,Teli Hsueh,David Linhart,Igor Vivanco,Jeffrey C. Lee,Julie H. Huang,Sethu Alexander,Jinyan Du,Tweeny R Kau,Roman K. Thomas,Kinjal Shah,Horacio Soto,Sven Perner,John R. Prensner,Ralph M. Debiasi,Francesca Demichelis,Charlie Hatton,Mark A. Rubin,Levi A. Garraway,Stan F. Nelson,Linda M. Liau,Paul S. Mischel,Timothy F. Cloughesy,Matthew Meyerson,Todd Golub,Eric S. Lander,Ingo K. Mellinghoff,William R. Sellers +30 more
TL;DR: A systematic method, called Genomic Identification of Significant Targets in Cancer (GISTIC), designed for analyzing chromosomal aberrations in cancer, is used to study gliomas and the results support the feasibility and utility of systematic characterization of the cancer genome.
Journal ArticleDOI
Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy
Robert M. Prins,Horacio Soto,Veerauo Konkankit,Sylvia K. Odesa,Ascia Eskin,William H. Yong,Stanley F. Nelson,Linda M. Liau +7 more
TL;DR: The results suggest that the mesenchymal gene expression profile may identify an immunogenic subgroup of glioblastoma that may be more responsive to immune-based therapies.
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An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway
Deliang Guo,Felicia Reinitz,Mary Youssef,Cynthia Hong,David Nathanson,David Akhavan,Daisuke Kuga,Ali Nael Amzajerdi,Horacio Soto,Shaojun Zhu,Ivan Babic,Kazuhiro Tanaka,Julie Dang,Akio Iwanami,Beatrice Gini,Jason DeJesus,Dominique Lisiero,Tiffany T. Huang,Robert M. Prins,Patrick Y. Wen,H. Ian Robins,Michael D. Prados,Lisa M. DeAngelis,Ingo K. Mellinghoff,Minesh P. Mehta,C. David James,Arnab Chakravarti,Timothy F. Cloughesy,Peter Tontonoz,Paul S. Mischel +29 more
TL;DR: Results show that EGFRvIII can promote tumor survival through PI3K/SREBP-1-dependent upregulation of LDLR and suggest a role for LXR agonists in the treatment of GBM patients.
Journal ArticleDOI
EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy.
Deliang Guo,Robert M. Prins,Julie Dang,Daisuke Kuga,Akio Iwanami,Horacio Soto,Kelly Y. Lin,Tiffany T. Huang,David Akhavan,M. Benjamin Hock,Shaojun Zhu,Ava A. Kofman,Steve J. Bensinger,William H. Yong,Harry V. Vinters,Steve Horvath,Andrew D. Watson,John G. Kuhn,H. Ian Robins,Minesh P. Mehta,Patrick Y. Wen,Lisa M. DeAngelis,Michael D. Prados,Ingo K. Mellinghoff,Timothy F. Cloughesy,Paul S. Mischel +25 more
TL;DR: Results identify a previously undescribed EGFR-mediated prosurvival metabolic pathway and suggest new therapeutic approaches to treating EG FR-activated glioblastomas.
Journal ArticleDOI
BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles
Walter W. Chen,Leonora Balaj,Linda M. Liau,Michael L. Samuels,Steve K. Kotsopoulos,Casey A. Maguire,Lori LoGuidice,Horacio Soto,Matthew C. Garrett,Lin Dan Zhu,Sarada Sivaraman,Clark C. Chen,Clark C. Chen,Eric T. Wong,Bob S. Carter,Fred H. Hochberg,Xandra O. Breakefield,Johan Skog +17 more
TL;DR: A novel approach that combines biofluid EV RNA and BEAMing RT-PCR, as well droplet digital PCR to interrogate mutations from glioma tumors is described, able to reliably detect and quantify mutant and wild-type IDH1 RNA transcripts in CSF of patients with gliomas.