R
Ralph M. Debiasi
Researcher at Harvard University
Publications - 7
Citations - 2848
Ralph M. Debiasi is an academic researcher from Harvard University. The author has contributed to research in topics: Gene & ERBB3. The author has an hindex of 7, co-authored 7 publications receiving 2743 citations. Previous affiliations of Ralph M. Debiasi include Massachusetts Institute of Technology & Broad Institute.
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Journal ArticleDOI
Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma
Rameen Beroukhim,Gad Getz,Leia Nghiemphu,Jordi Barretina,Teli Hsueh,David Linhart,Igor Vivanco,Jeffrey C. Lee,Julie H. Huang,Sethu Alexander,Jinyan Du,Tweeny R Kau,Roman K. Thomas,Kinjal Shah,Horacio Soto,Sven Perner,John R. Prensner,Ralph M. Debiasi,Francesca Demichelis,Charlie Hatton,Mark A. Rubin,Levi A. Garraway,Stan F. Nelson,Linda M. Liau,Paul S. Mischel,Timothy F. Cloughesy,Matthew Meyerson,Todd Golub,Eric S. Lander,Ingo K. Mellinghoff,William R. Sellers +30 more
TL;DR: A systematic method, called Genomic Identification of Significant Targets in Cancer (GISTIC), designed for analyzing chromosomal aberrations in cancer, is used to study gliomas and the results support the feasibility and utility of systematic characterization of the cancer genome.
Journal ArticleDOI
High-throughput oncogene mutation profiling in human cancer
Roman K. Thomas,Alissa C. Baker,Ralph M. Debiasi,Ralph M. Debiasi,Wendy Winckler,Wendy Winckler,Thomas LaFramboise,Thomas LaFramboise,William M. Lin,William M. Lin,Meng Wang,Meng Wang,Whei Feng,Whei Feng,Thomas Zander,Laura E. MacConnaill,Laura E. MacConnaill,Jeffrey C. Lee,Jeffrey C. Lee,Rick Nicoletti,Rick Nicoletti,Charlie Hatton,Charlie Hatton,Mary Goyette,Luc Girard,Kuntal Majmudar,Liuda Ziaugra,Kwok-Kin Wong,Stacey Gabriel,Rameen Beroukhim,Rameen Beroukhim,Michael Peyton,Jordi Barretina,Jordi Barretina,Amit Dutt,Amit Dutt,Caroline Emery,Heidi Greulich,Heidi Greulich,Kinjal Shah,Kinjal Shah,Hidefumi Sasaki,Adi F. Gazdar,John D. Minna,Scott A. Armstrong,Ingo K. Mellinghoff,F. Stephen Hodi,Glenn Dranoff,Paul S. Mischel,Timothy F. Cloughesy,Stan F. Nelson,Linda M. Liau,Kirsten D. Mertz,Kirsten D. Mertz,Mark A. Rubin,Holger Moch,Massimo Loda,William J. Catalona,Jonathan A. Fletcher,Sabina Signoretti,Frederic J. Kaye,Kenneth C. Anderson,George D. Demetri,Reinhard Dummer,Stephan N. Wagner,Meenhard Herlyn,William R. Sellers,William R. Sellers,Matthew Meyerson,Matthew Meyerson,Levi A. Garraway,Levi A. Garraway +71 more
TL;DR: High-throughput genotyping is adapted to query 238 known oncogene mutations across 1,000 human tumor samples and established robust mutation distributions spanning 17 cancer types, offering a new dimension in tumor genetics, where mutations involving multiple cancer genes may be interrogated simultaneously and in 'real time'.
Journal ArticleDOI
Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing
Roman K. Thomas,Elizabeth Nickerson,Jan Fredrik Simons,Pasi A. Jänne,Torstein Tengs,Torstein Tengs,Yuki Yuza,Levi A. Garraway,Levi A. Garraway,Thomas LaFramboise,Thomas LaFramboise,Jeffrey C. Lee,Jeffrey C. Lee,Kinjal Shah,Kinjal Shah,Keith O'Neill,Hidefumi Sasaki,Neal I. Lindeman,Kwok-Kin Wong,Ana M. Borras,Edward J. Gutmann,Konstantin H. Dragnev,Ralph M. Debiasi,Ralph M. Debiasi,Tzu Hsiu Chen,Tzu Hsiu Chen,Karen A. Glatt,Heidi Greulich,Heidi Greulich,Brian Desany,Christine Lubeski,William Brockman,Pablo Alvarez,Stephen K. Hutchison,John H. Leamon,Michael T. Ronan,Gregory S. Turenchalk,Michael Egholm,William R. Sellers,William R. Sellers,Jonathan M. Rothberg,Matthew Meyerson +41 more
TL;DR: It is shown that microreactor-based pyrosequencing can detect rare cancer-associated sequence variations by independent and parallel sampling of multiple representatives of a given DNA fragment and can thereby facilitate accurate molecular diagnosis of heterogeneous cancer specimens and enable patient selection for targeted cancer therapies.
Journal ArticleDOI
Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.
Jeffrey C. Lee,Jeffrey C. Lee,Igor Vivanco,Rameen Beroukhim,Rameen Beroukhim,Julie H. Y Huang,Whei Feng,Whei Feng,Ralph M. Debiasi,Ralph M. Debiasi,Koji Yoshimoto,J. King,Phioanh L. Nghiemphu,Yuki Yuza,Qing-Qing Xu,Heidi Greulich,Heidi Greulich,Roman K. Thomas,Roman K. Thomas,J. Guillermo Paez,J. Guillermo Paez,Timothy C. Peck,Timothy C. Peck,David Linhart,David Linhart,Karen A. Glatt,Gad Getz,Robert C. Onofrio,Liuda Ziaugra,Ross L. Levine,Stacey Gabriel,Tomohiro Kawaguchi,Keith O'Neill,Haumith Khan,Linda M. Liau,Stanley F. Nelson,P. Nagesh Rao,Paul S. Mischel,Russell O. Pieper,Timothy F. Cloughesy,Daniel J. Leahy,William R. Sellers,William R. Sellers,Charles L. Sawyers,Matthew Meyerson,Matthew Meyerson,Ingo K. Mellinghoff +46 more
TL;DR: The results suggest extracellular missense mutations as a novel mechanism for oncogenic EGFR activation and may help identify patients who can benefit from EGFR kinase inhibitors for treatment of glioblastoma.
Journal ArticleDOI
Erratum: Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing (Nature Medicine (2006) 12 (852-855))
Roman K. Thomas,Elizabeth Nickerson,Jan Fredrik Simons,Pasi A. Jänne,Torstein Tengs,Yuki Yuza,Levi A. Garraway,Thomas LaFramboise,Jeffrey C. Lee,Kinjal Shah,Keith O'Neill,Hidefumi Sasaki,Neal I. Lindeman,Kwok K. Wong,Ana M. Borras,Edward J. Gutmann,Konstantin H. Dragnev,Ralph M. Debiasi,Tzu Hsiu Chen,Karen A. Glatt,Heidi Greulich,Brian Desany,Christine Lubeski,William Brockman,Pablo Alvarez,Stephen K. Hutchison,John H. Leamon,Michael T. Ronan,Gregory S. Turenchalk,Michael Egholm,William R. Sellers,Jonathan M. Rothberg,Matthew Meyerson +32 more
TL;DR: In the version of this article initially published, it should have been acknowledged that Jan F. Simons, in addition to Roman K. Thomas and Elizabeth Nickerson, contributed equally to this work.