L
Lori LoGuidice
Researcher at Vanderbilt University
Publications - 5
Citations - 468
Lori LoGuidice is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Digital polymerase chain reaction & Mutant. The author has an hindex of 3, co-authored 5 publications receiving 355 citations.
Papers
More filters
Journal ArticleDOI
BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles
Walter W. Chen,Leonora Balaj,Linda M. Liau,Michael L. Samuels,Steve K. Kotsopoulos,Casey A. Maguire,Lori LoGuidice,Horacio Soto,Matthew C. Garrett,Lin Dan Zhu,Sarada Sivaraman,Clark C. Chen,Clark C. Chen,Eric T. Wong,Bob S. Carter,Fred H. Hochberg,Xandra O. Breakefield,Johan Skog +17 more
TL;DR: A novel approach that combines biofluid EV RNA and BEAMing RT-PCR, as well droplet digital PCR to interrogate mutations from glioma tumors is described, able to reliably detect and quantify mutant and wild-type IDH1 RNA transcripts in CSF of patients with gliomas.
Journal ArticleDOI
Detection of wild-Type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients
Javier M. Figueroa,Johan Karl Olov Skog,Johnny C. Akers,Hongying Li,Ricardo J. Komotar,Randy L. Jensen,Florian Ringel,Isaac Yang,Steven N. Kalkanis,Reid Thompson,Lori LoGuidice,Emily Berghoff,Andrew T. Parsa,Linda M. Liau,William T. Curry,Daniel P. Cahill,Chetan Bettegowda,Frederick F. Lang,E. Antonio Chiocca,John W. Henson,Ryan Y. Kim,Xandra O. Breakefield,Clark C. Chen,Karen Messer,Fred H. Hochberg,Bob S. Carter +25 more
TL;DR: The high specificity of the CSF-derived EV diagnostic test gives us an accurate determination of positive EGFRvIII tumor status and is essentially a less invasive "liquid biopsy" that might direct mutation-specific therapies for GBMs.
METHODS: ORIGINAL ARTICLE BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles
Walter W. Chen,Leonora Balaj,Linda M. Liau,Michael L. Samuels,Steve K. Kotsopoulos,Casey A. Maguire,Lori LoGuidice,Horacio Soto,Matthew Garrett,Lin Dan Zhu,Sarada Sivaraman,Clark C. Chen,Eric T. Wong,Bob S. Carter,Fred H. Hochberg,Xandra O. Breakefield,Johan Karl Olov Skog +16 more
TL;DR: In this article, a novel approach that combines biofluid EV RNA and BEAMing RT-PCR (EV-BEAMing), as well as droplet digital PCR to interrogate mutations from glioma tumors was presented.
Patent
A novel egfr variant
TL;DR: In this paper, a novel EGFR variant, EGFRvVI, was proposed and methods for detecting the new variant were presented. But, the method for detecting EGFRVVI may aid in the diagnosis, prognosis, and therapeutic assessment of a subject.
BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Patient Serum With Glioma and Cerebrospinal Fluid Extracellular Vesicles
Walter W. Chen,Leonora Balaj,Linda M. Liau,Michael L. Samuels,Steve K. Kotsopoulos,Casey A. Maguire,Lori LoGuidice,Horacio Soto,Matthew Garrett,Lin Dan Zhu,Sarada Sivaraman,Clark C. Chen,Eric T. Wong,Bob S. Carter,Fred H. Hochberg,Xandra O. Breakefield,Johan Karl Olov Skog +16 more