H
Horst Dürkop
Researcher at Charité
Publications - 60
Citations - 5296
Horst Dürkop is an academic researcher from Charité. The author has contributed to research in topics: CD30 & Apoptosis. The author has an hindex of 30, co-authored 60 publications receiving 5117 citations. Previous affiliations of Horst Dürkop include Free University of Berlin.
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Journal ArticleDOI
CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features.
Harald Stein,Hans-Dieter Foss,Horst Dürkop,Theresa Marafioti,Georges Delsol,Karen Pulford,Stefano Pileri,Brunangelo Falini +7 more
TL;DR: Recent immunohistologic studies suggest that ALCLs Hodgkin-like represent either cases of tumor cell-rich classic Hodgkin disease or (less commonly) ALK(+) ALCL orALK(-) ALCL, both of which have an unfavorable prognosis.
Journal ArticleDOI
Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease.
TL;DR: CDNAs coding for the HD characteristic antigen CD30 were cloned from expression libraries of the human HUT-102 cell line using the monoclonal antibodies Ki-1 and Ber-H2 and proved to be homologous to members of the nerve growth factor receptor superfamily.
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CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy.
Brunangelo Falini,S. A. Pileri,Giovanni Pizzolo,Horst Dürkop,L. Flenghi,F. Stirpe,M F Martelli,Harald Stein +7 more
TL;DR: The restricted distribution of the CD30 antigen in normal human tissues makes it a potential target for antibody-mediated therapy and prompted construction of anti-CD30 immunotoxins that have recently been clinically used and shown to display antitumor activity against refractory HD.
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BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope.
TL;DR: The diagnostic value of the Ber-H2 MoAb was most significant for a group of anaplastic large-cell lymphomas (ALC) lymphomas, of which more than 50 cases could be investigated, owing to applicability in paraffin sections.
Journal Article
PG-M1: A new monoclonal antibody directed against a fixative-resistant epitope on the macrophage-restricted form of the CD68 molecule
Brunangelo Falini,L. Flenghi,Stefano Pileri,Marcello Gambacorta,Barbara Bigerna,Horst Dürkop,F Eitelbach,Juergen Thiele,Roberta Pacini,A Cavaliere +9 more
TL;DR: A new anti-macrophage monoclonal antibody was produced by immunizing BALB/c mice with fresh spleen cells from a patient with Gaucher's disease, and the reactivity of the antibody with COS-1 and WOP cells transfected with a human complementary DNA clone encoding for the CD68 antigen suggests that PG-M1 is a new member of theCD68 cluster.