H
Hosni Sassi
Researcher at Gembloux Agro-Bio Tech
Publications - 8
Citations - 186
Hosni Sassi is an academic researcher from Gembloux Agro-Bio Tech. The author has contributed to research in topics: Population & Yarrowia. The author has an hindex of 6, co-authored 8 publications receiving 142 citations. Previous affiliations of Hosni Sassi include University of Liège & Université libre de Bruxelles.
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Journal ArticleDOI
A quantitative study of methanol/sorbitol co-feeding process of a Pichia pastoris Mut+/pAOX1-lacZ strain
Hongxing Niu,Laurent Jost,Nathalie Pirlot,Hosni Sassi,Marc Daukandt,Christian Rodriguez,Patrick Fickers +6 more
TL;DR: This study brings quantitative insight into the co-feeding process, which provides valuable data for the control of methanol/sorbitol co- feeding, aiming at enhancing biomass and heterologous protein productivities under given oxygen supply.
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Deciphering how LIP2 and POX2 promoters can optimally regulate recombinant protein production in the yeast Yarrowia lipolytica.
Hosni Sassi,Frank Delvigne,Tambi Kar,Jean-Marc Nicaud,Anne Marie Crutz Le A.M.C.L. Coq,Sébastien Steels,Patrick Fickers,Patrick Fickers +7 more
TL;DR: This study found that pLIP2 is a promoter of choice as compared to pPOX2 to drive gene expression for recombinant protein production by Y. lipolytica cultures grown in media supplemented with different carbon sources.
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Taking control over microbial populations: Current approaches for exploiting biological noise in bioprocesses.
Frank Delvigne,Jonathan Baert,Hosni Sassi,Patrick Fickers,Alexander Grünberger,Christian Dusny +5 more
TL;DR: This review focuses on recent progress made at describing, treating and exploiting biological noise in the context of microbial populations used in various bioprocess applications.
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Segregostat: a novel concept to control phenotypic diversification dynamics on the example of Gram-negative bacteria
Hosni Sassi,Thai Minh Nguyen,Samuel Telek,Guillermo Gosset,Alexander Grünberger,Frank Delvigne +5 more
TL;DR: The results prove that phenotypic diversification can be controlled by means of defined pulse‐frequency modulation within continuously running bioreactor set‐ups, laying the foundation for systematic studies, not only of phenotyping diversification but also for all processes where dynamics single‐cell approaches are required, such as synthetic co‐culture processes.
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Growth-dependent recombinant product formation kinetics can be reproduced through engineering of glucose transport and is prone to phenotypic heterogeneity
Juan Carlos Fragoso-Jiménez,Jonathan Baert,Thai Minh Nguyen,Wenzheng Liu,Hosni Sassi,Frédéric Goormaghtigh,Laurence Van Melderen,Paul Gaytán,Georgina Hernández-Chávez,Alfredo Martinez,Frank Delvigne,Guillermo Gosset +11 more
TL;DR: It is demonstrated that reduction on glucose consumption rate in E. coli leads to an improvement of GFP production and suggests reconsidering the generally accepted proposition stating that phenotypic heterogeneity is generally unwanted in bioprocess applications.