P
Peter Holding
Researcher at University of Oxford
Publications - 13
Citations - 3487
Peter Holding is an academic researcher from University of Oxford. The author has contributed to research in topics: Randomized controlled trial & Prostate cancer. The author has an hindex of 9, co-authored 12 publications receiving 2654 citations. Previous affiliations of Peter Holding include John Radcliffe Hospital.
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Journal ArticleDOI
10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer
Freddie C. Hamdy,Jenny L Donovan,J. Athene Lane,Malcolm David Mason,Chris Metcalfe,Peter Holding,Michael Davis,Tim J Peters,Emma L Turner,Richard M. Martin,Jon Oxley,M.C. Robinson,John Staffurth,Eleanor I Walsh,Prasad Bollina,James W.F. Catto,Andrew Doble,Alan Doherty,David Gillatt,Roger Kockelbergh,Howard Kynaston,Alan Paul,Philip Powell,Stephen Prescott,Derek J. Rosario,Edward Rowe,David E. Neal,David E. Neal +27 more
TL;DR: At a median of 10 years, prostate-cancer-specific mortality was low irrespective of the treatment assigned, with no significant difference among treatments.
Journal ArticleDOI
Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
Jenny L Donovan,Freddie C. Hamdy,J A Lane,Malcolm David Mason,Chris Metcalfe,Eleanor I Walsh,Jane M Blazeby,Tim J Peters,Peter Holding,Bonnington S,T Lennon,Lynne Bradshaw,Cooper D,Phillipa Herbert,Howson J,Arwyn Tomos Jones,Norma Lyons,Salter E,Pauline Thompson,Sarah Tidball,Jan Blaikie,Catherine Gray,Prasad Bollina,James W.F. Catto,Andrew Doble,Alan Doherty,David Gillatt,Roger Kockelbergh,Howard Kynaston,Alan Paul,Philip Powell,Stephen Prescott,Derek J. Rosario,Edward Rowe,Michael Davis,Emma L Turner,Richard M. Martin,David E. Neal,David E. Neal +38 more
TL;DR: In this analysis of patient-reported outcomes after treatment for localized prostate cancer, patterns of severity, recovery, and decline in urinary, bowel, and sexual function and associated quality of life differed among the three groups.
Journal ArticleDOI
Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality: The CAP Randomized Clinical Trial
Richard M. Martin,Richard M. Martin,Jenny L Donovan,Jenny L Donovan,Emma L Turner,Chris Metcalfe,Grace J. Young,Eleanor I Walsh,J. Athene Lane,Sian Noble,Steven E. Oliver,Simon Evans,Jonathan A C Sterne,Jonathan A C Sterne,Peter Holding,Yoav Ben-Shlomo,Yoav Ben-Shlomo,Peter Brindle,Naomi J Williams,Elizabeth M Hill,Siaw Yein Ng,Jessica Toole,Marta Tazewell,Laura J Hughes,Charlotte F Davies,Joanna Thorn,Elizabeth Down,George Davey Smith,David E. Neal,David E. Neal,Freddie C. Hamdy +30 more
TL;DR: There was no significant difference in prostate cancer mortality after a median follow-up of 10 years but the detection of low-risk prostate cancer cases increased and the findings do not support single PSA testing for population-based screening.
Journal ArticleDOI
Ten-year Mortality, Disease Progression, and Treatment-related Side Effects in Men with Localised Prostate Cancer from the ProtecT Randomised Controlled Trial According to Treatment Received
David E. Neal,Chris Metcalfe,Jenny L Donovan,J. Athene Lane,Michael Davis,Grace J. Young,Susan J Dutton,Eleanor I. Walsh,Richard M. Martin,Tim J Peters,Emma L Turner,Malcolm David Mason,Richard J. Bryant,Prasad Bollina,James W.F. Catto,Alan Doherty,David Gillatt,Vincent J. Gnanapragasam,Peter Holding,Owen Hughes,Roger Kockelbergh,Howard Kynaston,Jon Oxley,Alan Paul,Edgar Paez,Derek J. Rosario,Edward Rowe,John Staffurth,Doug G Altman,Freddie C. Hamdy,Andrew Doble,Philip Powell,Stephen Prescott,Derek Rosario,John Anderson,Jonathan Aning,Garett Durkan,Anthony Koupparis,Hing Y. Leung,Param Mariappan,Alan McNeill,Raj Persad,Hartwig Schwaibold,David N. Tulloch,Michael Wallace,Susan Bonnington,Lynne Bradshaw,Deborah Cooper,Emma Elliott,Phillipa Herbert,Joanne Howson,Amanda Jones,T Lennon,Norma Lyons,Hilary Moody,Claire Plumb,Tricia O'Sullivan,Elizabeth Salter,Pauline Thompson,Sarah Tidball,Jan Blaikie,Catherine Gray,Tonia Adam,Sarah Askew,Sharon Atkinson,Tim Baynes,Carole Brain,Viv Breen,Sarah Brunt,Sean Bryne,Jo Bythem,Jenny Clarke,Jenny Cloete,Susan Dark,Gill Davis,Rachael De La Rue,Jane Denizot,Elspeth Dewhurst,Anna Dimes,Nicola Dixon,Penny Ebbs,Ingrid Emmerson,Jill Ferguson,Ali Gadd,Lisa Geoghegan,Alison Grant,Collette Grant,Rosemary Godfrey,Louise Goodwin,Susie Hall,Liz Hart,Andrew Harvey,Chloe Hoult,Sarah Hawkins,Sharon Holling,Alastair Innes,Sue Kilner,Fiona Marshall,Louise Mellen,Andrea Moore,Sally Napier,Julie Needham,Kevin Pearse,Anna Pisa,Mark Rees,Ellie Richards,Lindsay Robson,Janet Roxburgh,Nikki Samuel,Irene Sharkey,Michael Slater,D. J. Smith,Pippa Taggart,Helen Taylor,Vicky Taylor,Ayesha Thomas,Briony Tomkies,Nicola Trewick,Claire Ward,Christy Walker,Ayesha Williams,C.R.J. Woodhouse,Elizabeth Wyber,Amit Bahl,Richard Benson,Mark Beresford,C.L. Ferguson,John Graham,Chris Herbert,Grahame Howard,Nicholas D. James,Peter Kirkbride,Alastair Law,Carmel Loughrey,Duncan McClaren,Helen Patterson,Ian Pedley,Trevor Roberts,Angus Robinson,Simon Russell,P. Symonds,Narottam Thanvi,Subramaniam Vasanthan,Paula Wilson,M.C. Robinson,Selina Bhattarai,Neeta Deshmukh,John Dormer,Malee Fernando,John R. Goepel,David J. Griffiths,Ken Grigor,Nick Mayer,Murali Varma,Anne Y. Warren,Helen Appleby,Dominic Ash,Dean Aston,Steven Bolton,Graham Chalmers,John Conway,Nick Early,Tony Geater,Lynda Goddall,Claire Heymann,Deborah Hicks,Liza Jones,Susan Lamb,Geoff Lambert,Gill Lawrence,Geraint Lewis,John Lilley,Aileen MacLeod,Pauline Massey,Alison McQueen,Rollo Moore,Lynda Penketh,Janet Potterton,Neil Roberts,Helen Showler,Pam Shuttleworth,Stephen Slade,Alasdair Steele,James Swinscoe,Marie Tiffany,John Townley,Jo Treeby,Michael Weston,Joyce Wilkinson,Lorraine Williams,Lucy Wills,O. Woodley,Sue Yarrow,Lucy Brindle,Linda Davies,D J Dedman,Elizabeth Down,Hanan Khazragui,Sian Noble,Hilary Taylor,Marta Tazewell,Julia Wade,Eleanor I Walsh,Susan Baker,Elizabeth Bellis-Sheldon,Chantal Bougard,Joanne Bowtell,Catherine Brewer,Chris Burton,Jennie Charlton,Nicholas Christoforou,Rebecca Clark,Susan Coull,Christine Croker,Rosemary Currer,Claire Daisey,Gill Delaney,Rose Donohue,Jane Drew,Rebecca Farmer,Susan Fry,Jean Haddow,Alex Hale,Susan Halpin,Belle Harris,Barbara Hattrick,Sharon Holmes,Helen Hunt,Vicky Jackson,Donna Johnson,Mandy Le Butt,Jo Leworthy,Tanya Liddiatt,Alex Martin,Jainee Mauree,Susan Moore,Gill Moulam,Jackie Mutch,Kathleen Parker,Christopher Pawsey,Michelle Purdie,Teresa Robson,Lynne Smith,Carole Stenton,Tom Steuart-Feilding,Beth Stott,Chris Sully,Caroline Sutton,Carol Torrington,Zoe Wilkins,Sharon Williams,Andrea Wilson,Ashleigh Weaver,Peter C. Albertsen,Jan Adolfsson,Michael Baum,Jon McFarlane,Colette Reid,Emma Turner,Anthony L. Zietman,Elizabeth M Hill,Siaw Yein Ng,Naomi J Williams,Jessica Toole,Charlotte F Davies,Laura J Hughes,Mari-Anne Rowlands,Lindsey Bell,Sean Harrison,Jainnee Mauree,Adrian Grant,Ian Roberts,Deborah Ashby,Richard A Cowan,Peter Fayers,Killian Mellon,James N'Dow,Tim O'Brien,Michael Sokhal,David P. Dearnaley,Fritz H. Schröder,Tracy E Roberts +281 more
TL;DR: Analyses according to treatment received showed increased rates of disease-related events and lower rates of patient-reported harms in menmanaged by AM compared with men managed by radical treatment, and stronger evidence of greater PCa mortality in the AM group.
Journal ArticleDOI
Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT.
Freddie C. Hamdy,Jenny L Donovan,J. Athene Lane,Malcolm David Mason,Chris Metcalfe,Peter Holding,Julia Wade,Sian Noble,Kirsty Garfield,Grace J. Young,Michael Davis,Tim J Peters,Emma L Turner,Richard M. Martin,Jon Oxley,M.C. Robinson,John Staffurth,Eleanor I Walsh,Jane M Blazeby,Richard J. Bryant,Prasad Bollina,James W.F. Catto,Andrew Doble,Alan Doherty,David Gillatt,Vincent J. Gnanapragasam,Owen Hughes,Roger Kockelbergh,Howard Kynaston,Alan Paul,Edgar Paez,Philip Powell,Stephen Prescott,Derek J. Rosario,Edward Rowe,David E. Neal +35 more
TL;DR: A prospective, multicentre prostate-specific antigen testing programme followed by a randomised trial of treatment, with a comprehensive cohort follow-up, to evaluate the effectiveness of conventional treatments for localised prostate cancer in men aged 50-69 years.