H
Howard S. Kruth
Researcher at National Institutes of Health
Publications - 127
Citations - 8013
Howard S. Kruth is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cholesterol & Cholesteryl ester. The author has an hindex of 46, co-authored 126 publications receiving 7543 citations.
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Journal ArticleDOI
Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells.
TL;DR: Procedures for the determination of free and total cholesterol in lipid extracts or sonicates of 10(4) cultured human skin fibroblasts are described, permitting one person to carry out analyses of 30 or more subcultures in one day.
Journal Article
Accumulation of cholesterol with age in human Bruch's membrane.
TL;DR: The cholesterol composition of normal human Bruch's membrane and choroid as a function of age and retinal location is determined to show that age-related maculopathy and atherosclerotic cardiovascular disease may share common pathogenic mechanisms.
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A defect in cholesterol esterification in Niemann-Pick disease (type C) patients
Peter G. Pentchev,Marcella E. Comly,Howard S. Kruth,Marie T. Vanier,David A. Wenger,Shutish C. Patel,Roscoe O. Brady +6 more
TL;DR: The error in cholesterol esterification may provide an opportunity for probing the molecular lesion in this disorder and may afford a useful and reliable means for establishing diagnosis.
Journal ArticleDOI
Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein.
Howard S. Kruth,Nancy L. Jones,Wei Huang,Bin Zhao,Itsuko Ishii,Janet Chang,Christian A. Combs,Daniela Malide,Wei-Yang Zhang +8 more
TL;DR: Macropinocytosis of LDL taken up in the fluid phase without receptor-mediated binding of LDL is a novel endocytic pathway that generates macrophage foam cells as a new pathway to target for modulating foam cell formation in atherosclerosis.
Journal ArticleDOI
Heterogeneity of human macrophages in culture and in atherosclerotic plaques.
Stephen W. Waldo,Stephen W. Waldo,Yifu Li,Chiara Buono,Bin Zhao,Eric M. Billings,Janet Chang,Howard S. Kruth +7 more
TL;DR: The identification of macrophage subpopulations with different gene expression patterns and, thus, different potentials for promoting atherosclerosis has important experimental and clinical implications and could prove to be a valuable finding in developing therapeutic interventions in diseases dependent on macrophages.