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Roberto J. Botelho
Researcher at Ryerson University
Publications - 83
Citations - 4630
Roberto J. Botelho is an academic researcher from Ryerson University. The author has contributed to research in topics: Phagocytosis & Phagosome. The author has an hindex of 30, co-authored 69 publications receiving 4000 citations. Previous affiliations of Roberto J. Botelho include Cornell University & University of Toronto.
Papers
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Journal ArticleDOI
Phagosome maturation: aging gracefully.
TL;DR: The determinants and consequences of the fusion and fission reactions that underlie phagosomal maturation are the topic of this review.
Journal ArticleDOI
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
Otilia V. Vieira,Otilia V. Vieira,Roberto J. Botelho,Lucia E. Rameh,Saskia M. Brachmann,Saskia M. Brachmann,Tsuyoshi Matsuo,Howard W. Davidson,Alan D. Schreiber,Jonathan M. Backer,Lewis C. Cantley,Sergio Grinstein +11 more
TL;DR: It is found that phosphatidylinositol 3-phosphate (PI[3]P) accumulates greatly but transiently on the phagosomal membrane, and the possibility that PI(3)P production by VPS34 may be targeted during the maturation arrest induced by some intracellular parasites is raised.
Journal ArticleDOI
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis
Roberto J. Botelho,Mary N. Teruel,Renee Dierckman,Richard A. Anderson,Alan Wells,John D. York,Tobias Meyer,Sergio Grinstein +7 more
TL;DR: The temporal sequence of phosphoinositide metabolism suggests that accumulation of 4,5-PIP2 is involved in the initial recruitment of actin to the phagocytic cup, while its degradation contributes to the subsequent cytoskeletal remodeling.
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Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis
Cameron C. Scott,Wendy Dobson,Roberto J. Botelho,Natasha Coady-Osberg,Philippe Chavrier,David A. Knecht,Colin M. Heath,Philip D. Stahl,Sergio Grinstein +8 more
TL;DR: Observations suggest that hydrolysis of PI(4,5)P2 dictates the remodeling of actin necessary for completion of phagocytosis.
Journal ArticleDOI
Phagosome Maturation: A Few Bugs in the System
TL;DR: The objective of this review is to summarize the current knowledge of the molecular mechanisms underlying phagosomal maturation and its subversion by parasitic microorganisms.