Y
Yoshio Hamada
Researcher at National Institute for Basic Biology, Japan
Publications - 30
Citations - 4155
Yoshio Hamada is an academic researcher from National Institute for Basic Biology, Japan. The author has contributed to research in topics: Notch signaling pathway & Trophoblast. The author has an hindex of 25, co-authored 30 publications receiving 4013 citations. Previous affiliations of Yoshio Hamada include University of Tokyo & National Institutes of Natural Sciences, Japan.
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Journal ArticleDOI
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.
Toshiki Saito,Shigeru Chiba,Motoshi Ichikawa,Atsushi Kunisato,Takashi Asai,Kiyoshi Shimizu,Tomoyuki Yamaguchi,Go Yamamoto,S Seo,Keiki Kumano,Etsuko Nakagami-Yamaguchi,Yoshio Hamada,Shinichi Aizawa,Hisamaru Hirai +13 more
TL;DR: It is demonstrated that Notch 2 but no other Notch family member is preferentially expressed in mature B cells and that conditionally targeted deletion of Notch2 results in the defect of marginal zone B (MZB) cells and their presumed precursors, CD1d(hi) fraction of type 2 transitional B cells.
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Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells
Keiki Kumano,Shigeru Chiba,Atsushi Kunisato,Masataka Sata,Toshiki Saito,Etsuko Nakagami-Yamaguchi,Tomoyuki Yamaguchi,Shigeo Masuda,Kiyoshi Shimizu,Tokiharu Takahashi,Seishi Ogawa,Yoshio Hamada,Hisamaru Hirai +12 more
TL;DR: It is shown that Notch1, but not Notch2, is essential for generating hematopoietic stem cells from endothelial cells, and in vitro and in vivo definitive hematobiology activities from YS and P-Sp were severely impaired in Notch 1(-/-) embryos.
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The carboxyl third of tau is tightly bound to paired helical filaments.
TL;DR: It is concluded that the carboxyl third of tau is tightly bound to PHF.
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Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality
TL;DR: The results indicate that Notch2 plays an essential role in postimplantation development in mice, probably in some aspect of cell specification and/or differentiation, and that the ankyrin repeats are indispensable for its function.
Journal ArticleDOI
Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods.
Kiyoshi Shimizu,Shigeru Chiba,Keiki Kumano,Noriko Hosoya,Tokiharu Takahashi,Yoshinobu Kanda,Yoshio Hamada,Yoshio Yazaki,Hisamaru Hirai +8 more
TL;DR: Deletion mutant analyses showed that Jagged1 binds to Notch1 and Notch3 in addition to NotCh2, suggesting that mJagged1 is a ligand for multiple Notch receptors, and a minimal binding unit and is indispensable for binding to mNotch2.