H
Hua Shun Li
Researcher at Washington University in St. Louis
Publications - 4
Citations - 1017
Hua Shun Li is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Slit & Eye development. The author has an hindex of 4, co-authored 4 publications receiving 995 citations.
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Journal ArticleDOI
Vertebrate Slit, a Secreted Ligand for the Transmembrane Protein Roundabout, Is a Repellent for Olfactory Bulb Axons
Hua Shun Li,Jin hui Chen,Wei Wu,Tanya Fagaly,Lijuan Zhou,Wenlin Yuan,Sophie Dupuis,Zhihong Jiang,William E. Nash,Carrie Gick,David M. Ornitz,Jane Y. Wu,Yi Rao +12 more
TL;DR: The isolation of vertebrate homologs of the Drosophila slit gene are reported and it is shown that Slit protein binds to the transmembrane protein Roundabout (Robo), establishing a ligand-receptor relationship between two molecules important for neural development and suggesting a role for Slit in olfactory bulb axon guidance.
Journal ArticleDOI
A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate
TL;DR: The results provide direct evidence for the existence of a single retina field, indicate that the retina field is resolved by suppression of retina formation in the median region of the field, and demonstrate that the prechordal plate plays a primary signaling role in retina field resolution.
Journal ArticleDOI
Cellular and Molecular Guidance of GABAergic Neuronal Migration from an Extracortical Origin to the Neocortex
TL;DR: It is found that the ventricular zone of the LGE is repulsive to GABAergic neuronal migration, and the secreted protein Slit is a chemorepellent guiding the migratory direction of GABAergic neurons, and blockade of endogenous Slit signaling inhibits the repulsive activity in the VZ.
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Embryonic expression and extracellular secretion of Xenopus Slit
TL;DR: The results confirm Slit-Roundabout interactions and the biochemical properties of Slit and Roundabout proteins, and further support the idea that Slit may guide axon projections in multiple regions of the embryo.