H
Huaibin Chen
Researcher at New York University
Publications - 15
Citations - 1330
Huaibin Chen is an academic researcher from New York University. The author has contributed to research in topics: Receptor tyrosine kinase & Phosphorylation. The author has an hindex of 13, co-authored 15 publications receiving 1154 citations. Previous affiliations of Huaibin Chen include Wenzhou Medical College.
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Journal ArticleDOI
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Huaibin Chen,Jinghong Ma,Wanqing Li,Anna V. Eliseenkova,Chong-Feng Xu,Thomas A. Neubert,W. Todd Miller,Moosa Mohammadi +7 more
TL;DR: Comparison of the crystal structures of unphosphorylated and phosphorylated wild-type FGFR2 kinase domains reveals an autoinhibitory "molecular brake" mediated by a triad of residues in the kinase hinge region of all FGFRs.
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Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex
Jun Fan,Changliang Shan,Hee-Bum Kang,Shannon Elf,Jianxin Xie,Meghan Ann Tucker,Ting-Lei Gu,Mike Aguiar,Lonning Scott Michael,Huaibin Chen,Moosa Mohammadi,Laura Mae P. Britton,Benjamin A. Garcia,Maša Alečković,Yibin Kang,Stefan Kaluz,Narra S. Devi,Erwin G. Van Meir,Taro Hitosugi,Jae Ho Seo,Sagar Lonial,Manila Gaddh,Martha Arellano,Hanna Jean Khoury,Fadlo R. Khuri,Titus J. Boggon,Sumin Kang,Jing Chen +27 more
TL;DR: It is reported that lysine acetylation of PDHA1 and PDP1 is common in epidermal growth factor-stimulated cells and diverse human cancer cells and contributes to the Warburg effect.
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Genetic Overlap in Kallmann Syndrome, Combined Pituitary Hormone Deficiency, and Septo-Optic Dysplasia
Taneli Raivio,Magdalena Avbelj,Mark J. McCabe,Christopher J. Romero,Andrew A. Dwyer,Johanna Tommiska,Gerasimos P. Sykiotis,Louise C. Gregory,Daniel Diaczok,Vaitsa Tziaferi,Mariet W. Elting,Raja Padidela,Lacey Plummer,Cecilia Martin,Bihua Feng,Chengkang Zhang,Qun-Yong Zhou,Huaibin Chen,Moosa Mohammadi,Richard Quinton,Yisrael Sidis,Sally Radovick,Mehul T. Dattani,Nelly Pitteloud +23 more
TL;DR: In this paper, the authors investigated whether Kallmann syndrome, combined pituitary hormone deficiency (CPHD), and septo-optic dysplasia (SOD) all result from development defects of the anterior midline in the human forebrain.
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Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma
Michael Gartside,Huaibin Chen,Omar A. Ibrahimi,Sara A. Byron,Amy Curtis,Candice L. Wellens,Ana Bengston,Laura M. Yudt,Anna V. Eliseenkova,Jinghong Ma,John A. Curtin,Pilar Hyder,Ursula Harper,Erica Riedesel,Graham J. Mann,Jeffrey M. Trent,Boris C. Bastian,Paul S. Meltzer,Moosa Mohammadi,Pamela M. Pollock +19 more
TL;DR: It is reported that 10% of melanoma tumors and cell lines harbor mutations in the fibroblast growth factor receptor 2 (FGFR2) gene, and it is suggested that FGFR2 may join the list of genes that play context-dependent opposing roles in cancer.
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The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, and ponatinib ATP-competitive inhibitors.
Sara A. Byron,Huaibin Chen,Andreas Wortmann,David Loch,Michael Gartside,Farhad Dehkhoda,Steven Blais,Thomas A. Neubert,Moosa Mohammadi,Pamela M. Pollock,Pamela M. Pollock +10 more
TL;DR: It is proposed that tumors harboring mutationally activated FGFRs should be treated with FGFR inhibitors that specifically bind the active kinase, and ponatinib is more effective than dovitinib at inhibiting FGFR2(N550K).