H
Huasong Lu
Researcher at Life Sciences Institute
Publications - 2
Citations - 246
Huasong Lu is an academic researcher from Life Sciences Institute. The author has contributed to research in topics: Innate immune system & RNA virus. The author has an hindex of 1, co-authored 2 publications receiving 16 citations.
Papers
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Journal ArticleDOI
Liquid-liquid phase separation in human health and diseases.
Bin Wang,Bin Wang,Zhang Lei,Tong Dai,Ziran Qin,Ziran Qin,Huasong Lu,Long Zhang,Fangfang Zhou +8 more
TL;DR: A review of liquid-liquid phase separation (LLPS) in eukaryotic cells can be found in this paper, where the authors describe the current understanding of LLPS and summarize its physiological functions.
Journal ArticleDOI
Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity.
Shuai Wang,Tong Dai,Ziran Qin,Ting Pan,Feng Chu,Lingfeng Lou,Long Zhang,Bing Yang,Bing Yang,Huizhe Huang,Huasong Lu,Fangfang Zhou +11 more
TL;DR: In this paper, the authors identified that the dimerization domain of the SARS-CoV-2 nucleocapsid protein (SARS2-NP) is required for SARS2NP to undergo liquid-liquid phase separation with RNA, which inhibits Lys63-linked poly-ubiquitination and aggregation of MAVS and thereby suppresses the innate antiviral immune response.