C
Cécile Tremblay
Researcher at Université de Montréal
Publications - 31
Citations - 5431
Cécile Tremblay is an academic researcher from Université de Montréal. The author has contributed to research in topics: Antibody & Virus. The author has an hindex of 25, co-authored 31 publications receiving 4638 citations. Previous affiliations of Cécile Tremblay include Harvard University.
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Journal ArticleDOI
On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection
Abstr Act,C. Capitant,Bruno Spire,Gilles Pialoux,Laurent Cotte,Isabelle Charreau,Cécile Tremblay,Eric Cua,Armelle Pasquet,François Raffi,Claire Pintado,Christian Chidiac,Julie Chas,P. Charbonneau,Constance Delaugerre,Marie Suzan-Monti,B. Loze,Gilles Peytavin,A Cheret,Julie Timsit,Gabriel Girard,Nicolas Lorente,Marie Préau,David Thompson,W. Rozenbaum,Véronique Doré,L. Marchand,C. Simon,N. Etien,Laurence Meyer +29 more
TL;DR: The use of TDF-FTC before and after sexual activity provided protection against HIV-1 infection in men who have sex with men, and the treatment was associated with increased rates of gastrointestinal and renal adverse events.
Journal ArticleDOI
High Rates of Forward Transmission Events after Acute/Early HIV-1 Infection
Bluma G. Brenner,Michel Roger,Jean-Pierre Routy,Daniela Moisi,Michel Ntemgwa,Claudine Matte,Jean-Guy Baril,Réjean Thomas,Danielle Rouleau,Julie Bruneau,Roger LeBlanc,Mario Legault,Cécile Tremblay,Hugues Charest,Mark A. Wainberg +14 more
TL;DR: Early infection accounts for approximately half of onward transmissions in this urban North American study, suggesting therapy at early stages of disease may prevent onward HIV transmission.
Journal ArticleDOI
Evolution and transmission of stable CTL escape mutations in HIV infection
Philip J. R. Goulder,Christian Brander,Yanhua Tang,Cécile Tremblay,Robert A. Colbert,Marylyn M. Addo,Eric S. Rosenberg,Thi Nguyen,Rachel L. Allen,Alicja Trocha,Marcus Altfeld,Suqin He,Michael Bunce,Robert Funkhouser,Stephen I. Pelton,Sandra K. Burchett,Kenneth McIntosh,Bette T. Korber,Bruce D. Walker +18 more
TL;DR: Investigation of mother–child transmission in the setting of HLA-B27 expression suggests that CTL escape mutations in epitopes associated with suppression of viraemia will accumulate as the epidemic progresses, and therefore have important implications for vaccine design.
Journal ArticleDOI
Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study
Jean-Michel Molina,Jean-Michel Molina,Isabelle Charreau,Bruno Spire,Laurent Cotte,Julie Chas,Catherine Capitant,Cécile Tremblay,Daniela Rojas-Castro,Eric Cua,Armelle Pasquet,Camille Bernaud,Claire Pintado,Constance Delaugerre,Constance Delaugerre,Luis Sagaon-Teyssier,Soizic Le Mestre,Christian Chidiac,Gilles Pialoux,Diane Ponscarme,Julien Fonsart,David Thompson,Mark A. Wainberg,Véronique Doré,Laurence Meyer,Laurence Meyer,Laurence Meyer,C Capitant,I Charreau,Emmanuelle Netzer,N Leturque,J Binesse,V. Foubert,M Saouzanet,F Euphrasie,Diane Carette,B Guillon,Y Saïdi,J P Aboulker,B Spire,M Suzan,G Cattin,Baptiste Demoulin,L Sagaon-Teyssier,Nicolas Lorente,V Doré,E Choucair,S Le Mestre,A Mennecier,N. Etien,M C Simon,A Diallo,S Gibowski,Jean-François Delfraissy,D Thompson,Jacquie Sas,J Pankovitch,Marina B. Klein,A Anis,Benoit Trottier,Jean-Guy Baril,Antoine Chéret,Michel Besnier,W. Rozenbaum,Nathalie Bajos,Julie Timsit,Gilles Peytavin,Isabelle Durand-Zaleski,Jean-Pierre Aboulker,Marie Suzan-Monti,Gabriel Girard,Daniela Rojas Castro,Marie Préau,Michel Morin,Anaïs Mennecier,Elias Choucair,Marie-Christine Simon,Joanne Otis,Alpha Diallo,Séverine Gibowski,Cecile Rabian +80 more
TL;DR: On-demand oral PrEP is highly effective at preventing HIV infection among high-risk men who have sex with men and therefore represents an alternative to daily PrEP, expanding choices for HIV prevention.
Journal ArticleDOI
Discovery and Characterization of Vicriviroc (SCH 417690), a CCR5 Antagonist with Potent Activity against Human Immunodeficiency Virus Type 1
Julie M. Strizki,Cécile Tremblay,Serena Xu,Lisa Wojcik,Nicole Wagner,Waldemar Gonsiorek,R. William Hipkin,Chuan-Chu Chou,Catherine Pugliese-Sivo,Yushi Xiao,Jayaram R. Tagat,Kathleen Cox,Tony Priestley,Steve Sorota,Wei Huang,Martin S. Hirsch,Gregory R. Reyes,Bahige M. Baroudy +17 more
TL;DR: A novel CCR5 antagonist, vicriviroc (formerly SCH-D or SCH 417690), is described, with improved antiviral activity and pharmacokinetic properties compared to those of SCH-C, a previously described C CR5 antagonist.