H
Hugues de Rocquigny
Researcher at French Institute of Health and Medical Research
Publications - 63
Citations - 2410
Hugues de Rocquigny is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Zinc finger & RNA. The author has an hindex of 25, co-authored 61 publications receiving 2278 citations. Previous affiliations of Hugues de Rocquigny include Goethe University Frankfurt & École normale supérieure de Cachan.
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First glimpses at structure-function relationships of the nucleocapsid protein of retroviruses.
TL;DR: The 3-D structures of HIV-1 and MoMuLV NC proteins, deduced from NMR studies, are characterized by a central globular domain with one (MoMuLV) or two (HIV-1) zinc fingers, which should facilitate a rational approach of new anti-HIV therapies based on inhibition of NC protein functions.
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NCp7 Activates HIV-1Lai RNA Dimerization by Converting a Transient Loop-Loop Complex into a Stable Dimer
TL;DR: The results show that the nucleocapsid protein NCp7 activates RNA dimerization very likely through interaction with the kissing complex and converts it into a stable dimer, and only occurs if the 240-280 stem-loop structure is present in HIV-1Lai RNA molecules and contains the autocomplementary G257CGCGC262 sequence.
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Production and neurotropism of lentivirus vectors pseudotyped with lyssavirus envelope glycoproteins.
Nathalie Desmaris,Assumpció Bosch,Christine Salaün,Caroline Petit,Marie-Christine Prévost,Noël Tordo,Pierre Perrin,Olivier Schwartz,Hugues de Rocquigny,Jean Michel Heard +9 more
TL;DR: Although coating HIV-1 particles with rabdhovirus envelope glycoproteins enables them to enter neuronal cells efficiently, pseudotyping is not sufficient to confer the powerful neurotropism of lyssaviruses to lentivirus vectors.
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Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis.
Hervé Beltz,Céline Clauss,Etienne Piémont,Damien Ficheux,Robert J. Gorelick,Bernard P. Roques,Caroline Gabus,Jean-Luc Darlix,Hugues de Rocquigny,Yves Mély +9 more
TL;DR: By fluorescence spectroscopy and gel electrophoresis, the NC structural determinants for cTAR binding and destabilization, and for the inhibition of self-primed DNA synthesis on a model system using a series of NC mutants and HIV-1 reverse transcriptase were identified.
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Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
Yves Mély,Hugues de Rocquigny,Volodymyr V. Shvadchak,Sergiy V. Avilov,Chang-Zhi Dong,Ursula Dietrich,Jean-Luc Darlix +6 more
TL;DR: New classes of molecules competing with NC or its viral nucleic acid and enzyme partners are reviewed here.