H
Hui Pen Tan
Researcher at Novartis Institute for Tropical Diseases
Publications - 3
Citations - 382
Hui Pen Tan is an academic researcher from Novartis Institute for Tropical Diseases. The author has contributed to research in topics: Systematic evolution of ligands by exponential enrichment & Aptamer. The author has an hindex of 2, co-authored 2 publications receiving 345 citations. Previous affiliations of Hui Pen Tan include Novartis.
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Journal ArticleDOI
An adenosine nucleoside inhibitor of dengue virus
Zheng Yin,Zheng Yin,Yen Liang Chen,Wouter Schul,Qing Yin Wang,Feng Gu,Jeyaraj Duraiswamy,Ravinder Reddy Kondreddi,Pornwaratt Niyomrattanakit,Suresh B. Lakshminarayana,Anne Goh,Hao Ying Xu,Wei Liu,Boping Liu,Joanne Y.H. Lim,Chuan Young Ng,Min Qing,Chin Chin Lim,Andy Yip,Gang Wang,Wai Ling Chan,Hui Pen Tan,Kai Lin,Bo Zhang,Gang Zou,Kristen A. Bernard,Christine E. Garrett,Karen Beltz,Min Dong,Margaret Weaver,Handan He,Arkadius Pichota,Véronique Dartois,Thomas H. Keller,Pei Yong Shi +34 more
TL;DR: The results have proved the concept that a nucleoside inhibitor could be developed for potential treatment of flavivirus infections and suppressed peak viremia, reduced cytokine elevation, and completely prevented the infected mice from death.
Journal ArticleDOI
Inhibition of Dengue Virus RNA Synthesis by an Adenosine Nucleoside
Yen Liang Chen,Zheng Yin,Jeyaraj Duraiswamy,Wouter Schul,Chin Chin Lim,Boping Liu,Hao Ying Xu,Min Qing,Andy Yip,Gang Wang,Wai Ling Chan,Hui Pen Tan,Melissa Lo,Sarah Liung,Ravinder Reddy Kondreddi,Ranga Rao,Helen Gu,Handan He,Thomas H. Keller,Pei Yong Shi +19 more
TL;DR: The results suggest that this adenosine inhibitor is phosphorylated to an active (triphosphate) form which functions as a chain terminator for viral RNA synthesis.
Posted ContentDOI
Success probability of high-affinity DNA aptamer generation by genetic alphabet expansion
TL;DR: In this paper , the authors reported a high affinity DNA aptamer generation method that introduces unnatural bases (UBs) as a fifth letter into the library, by genetic alphabet expansion.