J
Joanne Y.H. Lim
Researcher at University of Rochester
Publications - 9
Citations - 1119
Joanne Y.H. Lim is an academic researcher from University of Rochester. The author has contributed to research in topics: Virus & Interferon. The author has an hindex of 8, co-authored 9 publications receiving 1009 citations. Previous affiliations of Joanne Y.H. Lim include Novartis.
Papers
More filters
Journal ArticleDOI
An adenosine nucleoside inhibitor of dengue virus
Zheng Yin,Zheng Yin,Yen Liang Chen,Wouter Schul,Qing Yin Wang,Feng Gu,Jeyaraj Duraiswamy,Ravinder Reddy Kondreddi,Pornwaratt Niyomrattanakit,Suresh B. Lakshminarayana,Anne Goh,Hao Ying Xu,Wei Liu,Boping Liu,Joanne Y.H. Lim,Chuan Young Ng,Min Qing,Chin Chin Lim,Andy Yip,Gang Wang,Wai Ling Chan,Hui Pen Tan,Kai Lin,Bo Zhang,Gang Zou,Kristen A. Bernard,Christine E. Garrett,Karen Beltz,Min Dong,Margaret Weaver,Handan He,Arkadius Pichota,Véronique Dartois,Thomas H. Keller,Pei Yong Shi +34 more
TL;DR: The results have proved the concept that a nucleoside inhibitor could be developed for potential treatment of flavivirus infections and suppressed peak viremia, reduced cytokine elevation, and completely prevented the infected mice from death.
Journal ArticleDOI
Cholesterol biosynthesis modulation regulates dengue viral replication.
Christopher Rothwell,Aude LeBreton,Chuan Young Ng,Joanne Y.H. Lim,Wei Liu,Subhash G. Vasudevan,Mark Labow,Feng Gu,L. Alex Gaither +8 more
TL;DR: The data suggest genetic and pharmacological modulation of cholesterol biosynthesis can regulate dengue virus replication and that Renilla expression could be rescued in fluvastatin treated A549 Rluc-replicon cells after the addition of mevalonate.
Journal ArticleDOI
Type I interferons induced by radiation therapy mediate recruitment and effector function of CD8(+) T cells.
TL;DR: The capacity of radiation therapy to result in tumor control can be enhanced by using a unique inducible expression system to increase local levels of IFN-α exogenously, to further optimize the combination therapy strategy in terms of dosing and scheduling.
Journal ArticleDOI
Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity.
Dirk G. Brockstedt,Keith S. Bahjat,Martin A. Giedlin,W Liu,M Leong,William S. Luckett,Y Gao,Pamela Schnupf,D Kapadia,G Castro,Joanne Y.H. Lim,Adam Sampson-Johannes,Anat A. Herskovits,A Stassinopoulos,H. G. Archie Bouwer,John E. Hearst,Daniel A. Portnoy,Daniel A. Portnoy,David N. Cook,Thomas W. Dubensky +19 more
TL;DR: A new class of vaccines is developed, based on killed but metabolically active (KBMA) bacteria, that simultaneously takes advantage of the potency of live vaccines and the safety of killed vaccines, and provides therapeutic benefit in a mouse cancer model.
Journal ArticleDOI
Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel
Pornwaratt Niyomrattanakit,Yen Liang Chen,Hongping Dong,Zheng Yin,Zheng Yin,Min Qing,J. Frasier Glickman,J. Frasier Glickman,Kai Lin,Dieter Mueller,Hans Voshol,Joanne Y.H. Lim,Shahul Nilar,Thomas H. Keller,Pei Yong Shi +14 more
TL;DR: This study has provided direct evidence to support the hypothesis that allosteric pockets from flavivirus RdRp could be targeted for antiviral development.