Hui Qiao

TL;DR: It is demonstrated that LN-resident lymphatic endothelial cells express multiple peripheral tissue antigens (PTAs) independent of the autoimmune regulator (Aire), and that other LN stromal subpopulations express distinct PTAs by mechanisms that vary in their Aire dependence.

TL;DR: It is shown that rescue of tyrosinase-specific T(CD8) by interference with PD-1 or provision of costimulation results in autoimmune vitiligo, demonstrating that LECs are significant, albeit suboptimal, antigen-presenting cells.

TL;DR: It is concluded that spermiation, a physiological checkpoint in spermatogenesis, determines the egress and tolerogenicity of MGCA, and this findings will affect target antigen selection in testis and sperm autoimmunity and the immune responses to CTA in male cancer patients.

TL;DR: Evidence is provided that the ovarian Ag develops at birth, 14 days earlier than prostate Ag, and that male Tregs respond to neonatal ovarian Ag in the Treg recipients to gain AOD-suppressing capacity, concluding that the physiologic autoAg quickly and continuously enhances disease-specific polyclonal Treg function to maintain self-tolerance.

TL;DR: This model of tick-induced IgE responses could be used to study the factors within tick bites that cause allergies and to investigate how sensitization to food Ags occurs through the skin that leads to IgE production.