J
Jarish N. Cohen
Researcher at University of California, San Francisco
Publications - 34
Citations - 1653
Jarish N. Cohen is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 15, co-authored 28 publications receiving 1177 citations. Previous affiliations of Jarish N. Cohen include University of Virginia & University of Pennsylvania.
Papers
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Journal ArticleDOI
Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation
Jarish N. Cohen,Cynthia J. Guidi,Eric F. Tewalt,Hui Qiao,Sherin J. Rouhani,Alanna Ruddell,Andrew G. Farr,Kenneth S. K. Tung,Victor H. Engelhard +8 more
TL;DR: It is demonstrated that LN-resident lymphatic endothelial cells express multiple peripheral tissue antigens (PTAs) independent of the autoimmune regulator (Aire), and that other LN stromal subpopulations express distinct PTAs by mechanisms that vary in their Aire dependence.
Journal ArticleDOI
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Eric F. Tewalt,Jarish N. Cohen,Sherin J. Rouhani,Cynthia J. Guidi,Hui Qiao,Shawn P. Fahl,Mark R. Conaway,Timothy P. Bender,Kenneth S. K. Tung,Anthony T. Vella,Adam J. Adler,Lieping Chen,Victor H. Engelhard +12 more
TL;DR: It is shown that rescue of tyrosinase-specific T(CD8) by interference with PD-1 or provision of costimulation results in autoimmune vitiligo, demonstrating that LECs are significant, albeit suboptimal, antigen-presenting cells.
Journal ArticleDOI
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction
Sherin J. Rouhani,Jacob D. Eccles,Priscila Riccardi,J. David Peske,Eric F. Tewalt,Jarish N. Cohen,Roland S. Liblau,Taija Makinen,Victor H. Engelhard +8 more
TL;DR: Lymphatic endothelial cells (LECs) serve as an antigen reservoir for CD4 T-cell tolerance, and MHC-II molecules on LECs are used to induce CD8 T- cell tolerance via LAG-3.
Journal ArticleDOI
Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair
TL;DR: This Review summarizes the recent advances in the understanding of the roles of regulatory T cells in skin injury and tissue repair and focuses on recently discovered interactions between lymphocytes and nonhematopoietic cells during wound healing.
Journal ArticleDOI
Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment.
Jarish N. Cohen,Eric F. Tewalt,Sherin J. Rouhani,Erica L. Buonomo,Amber N. Bruce,Xiaojiang Xu,Stefan Bekiranov,Yang Xin Fu,Victor H. Engelhard +8 more
TL;DR: This article showed that lymphatic endothelial cells in the lymph node medullary sinus express the highest levels of peripheral tissue antigens and PD-L1, and are the only subpopulation that expresses tyrosinase epitope.