H
Hui Qiao
Researcher at University of Virginia
Publications - 8
Citations - 738
Hui Qiao is an academic researcher from University of Virginia. The author has contributed to research in topics: Immune tolerance & Cytotoxic T cell. The author has an hindex of 7, co-authored 8 publications receiving 625 citations. Previous affiliations of Hui Qiao include Georgia Regents University.
Papers
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Journal ArticleDOI
Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation
Jarish N. Cohen,Cynthia J. Guidi,Eric F. Tewalt,Hui Qiao,Sherin J. Rouhani,Alanna Ruddell,Andrew G. Farr,Kenneth S. K. Tung,Victor H. Engelhard +8 more
TL;DR: It is demonstrated that LN-resident lymphatic endothelial cells express multiple peripheral tissue antigens (PTAs) independent of the autoimmune regulator (Aire), and that other LN stromal subpopulations express distinct PTAs by mechanisms that vary in their Aire dependence.
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Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Eric F. Tewalt,Jarish N. Cohen,Sherin J. Rouhani,Cynthia J. Guidi,Hui Qiao,Shawn P. Fahl,Mark R. Conaway,Timothy P. Bender,Kenneth S. K. Tung,Anthony T. Vella,Adam J. Adler,Lieping Chen,Victor H. Engelhard +12 more
TL;DR: It is shown that rescue of tyrosinase-specific T(CD8) by interference with PD-1 or provision of costimulation results in autoimmune vitiligo, demonstrating that LECs are significant, albeit suboptimal, antigen-presenting cells.
Journal ArticleDOI
Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance
Kenneth S. K. Tung,Jessica Harakal,Hui Qiao,Claudia Rival,Jonathan C. H. Li,Alberta Ga. Paul,Karen Wheeler,Patcharin Pramoonjago,Constance M. Grafer,Wei Sun,Robert D. Sampson,Elissa W.P. Wong,Prabhakara P. Reddi,Umesh S. Deshmukh,Daniel M. Hardy,Huanghui Tang,C. Yan Cheng,Erwin Goldberg +17 more
TL;DR: It is concluded that spermiation, a physiological checkpoint in spermatogenesis, determines the egress and tolerogenicity of MGCA, and this findings will affect target antigen selection in testis and sperm autoimmunity and the immune responses to CTA in male cancer patients.
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Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+ CD25+ regulatory T cells.
Yulius Setiady,Katsuhiro Ohno,Katsuhiro Ohno,Eileen Samy,Eileen Samy,Harini Bagavant,Harini Bagavant,Hui Qiao,Hui Qiao,Colin P. Sharp,Jin Xiong She,Jin Xiong She,Kenneth S. K. Tung,Kenneth S. K. Tung +13 more
TL;DR: Evidence is provided that the ovarian Ag develops at birth, 14 days earlier than prostate Ag, and that male Tregs respond to neonatal ovarian Ag in the Treg recipients to gain AOD-suppressing capacity, concluding that the physiologic autoAg quickly and continuously enhances disease-specific polyclonal Treg function to maintain self-tolerance.
Journal ArticleDOI
Cutaneous Exposure to Clinically Relevant Lone Star Ticks Promotes IgE Production and Hypersensitivity through CD4+ T Cell- and MyD88-Dependent Pathways in Mice.
Jessica L. Chandrasekhar,Kelly M. Cox,William M. Loo,Hui Qiao,Kenneth S. K. Tung,Loren D. Erickson +5 more
TL;DR: This model of tick-induced IgE responses could be used to study the factors within tick bites that cause allergies and to investigate how sensitization to food Ags occurs through the skin that leads to IgE production.