Hui Sheng

TL;DR: The authors identified and validated a methylation-based diagnostic score to help distinguish patients with colorectal cancer from healthy controls, as well as a prognostic score that correlated with patients’ survival, and found that a single ctDNA methylation marker could yield high sensitivity and specificity for identifying patients with cancer.

TL;DR: The ferroptosis potential index (FPI) was established to reveal the functional roles of ferroPTosis and noticed that the FPI was higher in tumors than in normal tissues in most cancers and was associated with subtypes and clinical features.

TL;DR: Analysis of frequency and clinicopathological features of metastasis to liver, lung, bone, and brain from GC patients found African‐Americans had the highest risk of liver metastasis and Caucasian had the high prone to develop lung and brain metastasis.

TL;DR: Disruption of DUSP6 by BCI enhanced CDDP-induced cell death and apoptosis in GC may partly through ERK and DDR pathways, which suggests that D USP6 is a potential prognostic biomarker and a promising target for GC therapy.

TL;DR: A novel regulatory mechanism for Nampt in PDAC is revealed and it is suggested that Nampt inhibition may override gemcitabine resistance by decreasing the NAD level and suppressing glycolytic activity, warranting further clinical investigation for pancreatic cancer treatment.