Xiaoke Hao

TL;DR: This work identified an HCC-specific methylation marker panel by comparing HCC tissue and normal blood leukocytes and showed that methylation profiles of HCC tumour DNA and matched plasma ctDNA are highly correlated.

TL;DR: The utility of DNA methylation profiles for differentiating tumors and normal tissues for four common cancers found that they could differentiate cancerous tissue from normal tissue with >95% accuracy and can predict prognosis and survival.

TL;DR: The authors identified and validated a methylation-based diagnostic score to help distinguish patients with colorectal cancer from healthy controls, as well as a prognostic score that correlated with patients’ survival, and found that a single ctDNA methylation marker could yield high sensitivity and specificity for identifying patients with cancer.

TL;DR: In this paper, gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors was performed via gene-and mutation-independent therapy.

TL;DR: It is suggested that exosome-derived lncRNA TCONS_00072128 could promote the progression of PMOP by regulating caspase 8 and was possible to be a key regulator that balanced cell differentiation and inflammation activation.