H
Hui Wang
Researcher at Minzu University of China
Publications - 33
Citations - 529
Hui Wang is an academic researcher from Minzu University of China. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 25 publications receiving 330 citations. Previous affiliations of Hui Wang include Laboratory of Molecular Biology & Northwest A&F University.
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Journal ArticleDOI
SCD1 Alters Long-Chain Fatty Acid (LCFA) Composition and Its Expression Is Directly Regulated by SREBP-1 and PPARγ 1 in Dairy Goat Mammary Cells.
Dawei Yao,Jun Luo,Qiuya He,Hengbo Shi,Jun Li,Hui Wang,Huifen Xu,Zhi Chen,Yongqing Yi,Juan J. Loor +9 more
TL;DR: It is demonstrated that SCD1 expression in goat mammary tissue is higher during lactation than the dry period, underscoring an important role of the enzyme and this transcription regulator in controlling mammary gland lipid synthesis in the goat.
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Inhibition of FASN reduces the synthesis of medium-chain fatty acids in goat mammary gland.
TL;DR: This study provides a direct evidence for inhibition of FASN reduces cellular medium-chain fatty acids synthesis in goat mammary gland epithelial cells (GMEC) in GMEC.
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MiR-145 Regulates Lipogenesis in Goat Mammary Cells Via Targeting INSIG1 and Epigenetic Regulation of Lipid-Related Genes
TL;DR: It is revealed that miR‐145 regulates metabolism of fatty acids in goat mammary gland epithelial cells (GMEC) and is a direct target of insulin induced gene 1 (INSIG1), which underscores the need for further studies to evaluate the potential for targeting miRNAs for improving beneficial milk components in ruminant milk.
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MicroRNA-26a/b and their host genes synergistically regulate triacylglycerol synthesis by targeting the INSIG1 gene.
TL;DR: The findings highlight a functional association of miR-26a/b, their host genes and INSIG1, and provide new insights into the regulatory network controlling milk fat synthesis in GMEC, indicating that targeting this network via nutrition might be important for regulating milkfat synthesis in ruminants.
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MicroRNA-24 can control triacylglycerol synthesis in goat mammary epithelial cells by targeting the fatty acid synthase gene
TL;DR: Overexpression or downregulation of miR-24 in goat mammary epithelial cells (GMEC) strongly affected fatty acid profiles; in particular, miR -24 enhanced unsaturated fatty acid concentration and Luciferase reporter assay confirmed that fatty acid synthase is a target of mi R-24.