Yue Ma

TL;DR: The findings highlight a functional association of miR-26a/b, their host genes and INSIG1, and provide new insights into the regulatory network controlling milk fat synthesis in GMEC, indicating that targeting this network via nutrition might be important for regulating milkfat synthesis in ruminants.

TL;DR: It is found that PRL was significantly down‐regulated in response to the expression of miR‐135b in a manner that was functionally related to TAG synthesis via the large tumor suppressor 2 gene (Lats2), an important regulator of adipocyte proliferation via Hippo Signaling.

TL;DR: The results indicated that t10c12-CLA inhibits fatty acid synthesis through downregulation of genes involved in de novo fatty acids synthesis, and this process is likely correlated with the activation of the AMP-activated protein kinase signaling pathways.

TL;DR: The data indicate that a side effect of de novo fatty acid synthesis inhibition by t10c12-CLA is the up-regulation of fatty acid uptake and accumulation of lipid droplets in GMECs.

TL;DR: The findings indicated EGF might be beneficial to improve milk fat synthesis of dairy goats and play an important role in regulating de novo fatty acid synthesis in GMECs, mainly mediated by Akt and PLC-γ1 signaling pathways.