Huihua Yuan

TL;DR: Biological assay results corroborated that the fibrous PLMC scaffolds were cytocompatible by supporting osteoblast adhesion and proliferation, and functionally promoted biomineralization-relevant alkaline phosphatase expression and mineral deposition.

TL;DR: It is shown that the stepwise physical substrate change strategy can be adopted to induce hiPSCs differentiation for tendon tissue regeneration and confirmed that aligned fiber scaffold with hiPSC-MSCs had significant effect on improving the structural and mechanical properties of tendon injury repair.

TL;DR: Investigation of osteogenic differentiation and bone regeneration capacities of iPSC-MSCs by using biomimetic nanofibers of hydroxyapatite/collagen/chitosan (HAp/Col/CTS) suggests that nan ofibrous scaffold supported iPSSCs complex may be a new 'stem cell-scaffold' system for regulating the fate of osteogenicity towards patient-specific bone regeneration in future.

TL;DR: Electrospun GT/PCL and other similar natural-synthetic hybrid systems in constructing tissue-engineered scaffolds may offer a facile and effective approach to achieve finer and compositionally homogeneous hybrid nanofibers for effective applications.

TL;DR: This study suggests that introduction of an elliptical nano-pore feature to the aligned microfiber surfaces could provide additional dimensionality of topographical cues to modulate the vSMC responses when using the aligned electrospun ultrafine fibers for engineering vascular constructs.