H
Hun-Way Hwang
Researcher at University of Pittsburgh
Publications - 18
Citations - 4450
Hun-Way Hwang is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: microRNA & Gene. The author has an hindex of 11, co-authored 16 publications receiving 4165 citations. Previous affiliations of Hun-Way Hwang include National Institutes of Health & Rockefeller University.
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Journal ArticleDOI
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
Janaiah Kota,Raghu R. Chivukula,Kathryn A. O'Donnell,Erik A. Wentzel,Chrystal L. Montgomery,Hun-Way Hwang,Tsung Cheng Chang,Perumal Vivekanandan,Michael Torbenson,K. Reed Clark,K. Reed Clark,Jerry R. Mendell,Jerry R. Mendell,Joshua T. Mendell +13 more
TL;DR: It is demonstrated that hepatocellular carcinoma (HCC) cells exhibit reduced expression of miR-26a, a miRNA that is normally expressed at high levels in diverse tissues that may provide a general strategy for miRNA replacement therapies.
Journal ArticleDOI
MicroRNAs in cell proliferation, cell death, and tumorigenesis.
Hun-Way Hwang,Joshua T. Mendell +1 more
TL;DR: How miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors is discussed.
Journal ArticleDOI
A hexanucleotide element directs microRNA nuclear import.
TL;DR: The results indicate that miRNAs sharing common 5′ sequences, considered to be largely redundant, might have distinct functions because of the influence of cis-acting regulatory motifs.
Journal ArticleDOI
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation
Tsung Cheng Chang,Lauren R Zeitels,Hun-Way Hwang,Raghu R. Chivukula,Erik A. Wentzel,Michael Dews,Jason J. Jung,Ping Gao,Chi V. Dang,Michael A. Beer,Andrei Thomas-Tikhonenko,Joshua T. Mendell +11 more
TL;DR: It is shown that Myc induces Lin-28B expression in multiple human and mouse tumor models and an orchestration of transcriptional and posttranscriptional mechanisms in Myc-mediated reprogramming of miRNA expression is uncovered.
Journal ArticleDOI
Cell–cell contact globally activates microRNA biogenesis
TL;DR: It is demonstrated that miRNAs are subject to dynamic posttranscriptional regulation in widely used cell culture systems and may provide insight into mechanisms that influence miRNA expression in physiologic and pathophysiologic states.