K. Reed Clark

TL;DR: It is demonstrated that hepatocellular carcinoma (HCC) cells exhibit reduced expression of miR-26a, a miRNA that is normally expressed at high levels in diverse tissues that may provide a general strategy for miRNA replacement therapies.

TL;DR: It is demonstrated that deletion of mouse Mir122 resulted in hepatosteatosis, hepatitis, and the development of tumors resembling HCC, demonstrating critical functions for miR-122 in the maintenance of liver homeostasis and have important therapeutic implications, including the potential utility of mi R-122 delivery for selected patients with HCC and the need for careful monitoring of patients receiving miR -122 inhibition therapy for HCV.

TL;DR: Using the simian immunodeficiency virus (SIV) model, long-lasting neutralizing activity in serum is generated and monkeys are observed to have complete protection against intravenous challenge with virulent SIV.

TL;DR: Recombinant adeno-associated virus (rAAV) vectors are promising human gene transfer vectors, because they mediate long-term gene expression in vivo and the majority of the rAAV vector DNA in muscle persisted over time as transcriptionally active monomeric and concatameric episomes.

TL;DR: A viral approach with AAV for selective long-term reporter gene (GFP) expression in MCH neurons is developed, allowing the study of their cellular physiology in hypothalamic slices and support the view that M CH neurons may integrate information within the arousal system in favor of energy conservation.