H
Hung Yu Sun
Researcher at National Cheng Kung University
Publications - 19
Citations - 410
Hung Yu Sun is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: Lipoprotein & Internal medicine. The author has an hindex of 8, co-authored 15 publications receiving 337 citations.
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Journal ArticleDOI
Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells.
Jin-Ching Lee,Chin Kai Tseng,Kung Chia Young,Hung Yu Sun,Shainn Wei Wang,Wei-Chun Chen,Chun-Kuang Lin,Yu Hsuan Wu +7 more
TL;DR: This study aimed to evaluate the anti‐hepatitis C virus activity of andrographolide, a diterpenoid lactone extracted from Andrographis paniculata, and to identify the signalling pathway involved in its antiviral action.
Journal ArticleDOI
Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins.
Hung Yu Sun,Sun Fang Chen,Ming Derg Lai,Ting-Tsung Chang,Tz Li Chen,Pei Yu Li,Dar-Bin Shieh,Kung Chia Young +7 more
TL;DR: The VLDL- and LDL lipoproteomes and the full-spectrum protein changes during physiological V LDL-to-LDL transition are revealed and are potentially applied to the development of diagnostics.
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Apolipoprotein J, a glucose-upregulated molecular chaperone, stabilizes core and NS5A to promote infectious hepatitis C virus virion production
Chun Chieh Lin,Peiju Tsai,Hung Yu Sun,Mei Chi Hsu,Jin-Ching Lee,I-Chin Wu,Chiung Wen Tsao,Ting-Tsung Chang,Kung Chia Young +8 more
TL;DR: The interplay between glucose, ApoJ and HCV virion production is investigated, which facilitates infectious HCV particle production via stabilization of core/NS5A, which might surround LDs at the ER-Golgi membrane contact site.
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Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III
Hung Yu Sun,Chun Chieh Lin,Jin-Ching Lee,Shainn Wei Wang,Pin-Nan Cheng,I-Chin Wu,Ting-Tsung Chang,Ming Derg Lai,Dar-Bin Shieh,Kung Chia Young +9 more
TL;DR: This study reveals that LPL is an anti-HCV factor, and that apoC-III in VLDL and LVPs reduces the LPL-mediated inhibition of HCV infection.
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Favouring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic HCV infection
TL;DR: The DAA treatment of patients with chronic hepatitis C might lead to efficient HCV eradication and hepatic improvement concomitantly evolving with favouring lipoprotein/apo metabolisms.