H
Hyeyoun Chang
Researcher at Korea Institute of Science and Technology
Publications - 22
Citations - 692
Hyeyoun Chang is an academic researcher from Korea Institute of Science and Technology. The author has contributed to research in topics: Cancer & Immunology. The author has an hindex of 8, co-authored 16 publications receiving 427 citations. Previous affiliations of Hyeyoun Chang include Korea University of Science and Technology & Harvard University.
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Journal ArticleDOI
ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer
Dong Gil You,Dong Gil You,V. G. Deepagan,Wooram Um,Wooram Um,Sangmin Jeon,Sangmin Jeon,Sejin Son,Hyeyoun Chang,Hwa In Yoon,Hwa In Yoon,Yong Woo Cho,Maggie Swierczewska,Seulki Lee,Martin G. Pomper,Ick Chan Kwon,Kwangmeyung Kim,Jae Hyung Park +17 more
TL;DR: This study provides the first demonstration of the feasibility of using HTiO2 NPs as sensitizers for sonodynamic therapy in vivo, and effectively suppressed the growth of superficial tumours after ultrasound treatments.
Journal ArticleDOI
Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment.
Jooho Park,Yongwhan Choi,Yongwhan Choi,Hyeyoun Chang,Hyeyoun Chang,Wooram Um,Ju Hee Ryu,Ick Chan Kwon,Ick Chan Kwon,Ick Chan Kwon +9 more
TL;DR: Current attempts at overcoming the limitations of traditional EPR-dependent nanomedicine by incorporating supplementary strategies, such as additional molecular targeting, physical alteration, or physiological remodeling of the tumor microenvironment are focused on.
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Effects of tumor microenvironments on targeted delivery of glycol chitosan nanoparticles.
Ji Young Yhee,Sangmin Jeon,Hong Yeol Yoon,Man Kyu Shim,Hyewon Ko,Jiwoong Min,Jin Hee Na,Hyeyoun Chang,Hyounkoo Han,Jong Ho Kim,Minah Suh,Hyukjin Lee,Jae Hyung Park,Kwangmeyung Kim,Kwangmeyung Kim,Ick Chan Kwon,Ick Chan Kwon +16 more
TL;DR: This comprehensive study provides substantial evidence that the EPR effects based tumor‐targeted delivery of nanoparticles can be different depending on the tumor microenvironment in individual tumors.
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Bioorthogonal Copper Free Click Chemistry for Labeling and Tracking of Chondrocytes In Vivo.
Hwa In Yoon,Hwa In Yoon,Ji Young Yhee,Jin Hee Na,Sangmin Lee,Hyukjin Lee,Sun-Woong Kang,Hyeyoun Chang,Ju Hee Ryu,Seulki Lee,Ick Chan Kwon,Yong Woo Cho,Kwangmeyung Kim +12 more
TL;DR: A new method for cell labeling and tracking by combining metabolic gylcoengineering and bioorthogonal copper-free Click chemistry is introduced, which presented strong NIRF signals with relatively low cytotoxicity and had minimal effect on cartilage formation in vivo.
Journal ArticleDOI
Predicting the in vivo accumulation of nanoparticles in tumor based on in vitro macrophage uptake and circulation in zebrafish.
Hyeyoun Chang,Ji Young Yhee,Gun Hyuk Jang,Dong Gil You,Ju Hee Ryu,Yongwhan Choi,Jin Hee Na,Jae Hyung Park,Kwan Hyi Lee,Kuiwon Choi,Kwangmeyung Kim,Ick Chan Kwon,Ick Chan Kwon +12 more
TL;DR: Differences in physicochemical properties and in vitro cancer cell/macrophage uptake of 5 different nanoparticles with mean diameter of 200-250nm were comparatively analyzed, along with their circulation in adult zebrafish, to predict the in vivo fates of nanoparticles in tumor-bearing mice.