S
Seulki Lee
Researcher at Johns Hopkins University School of Medicine
Publications - 171
Citations - 14987
Seulki Lee is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: In vivo & PEGylation. The author has an hindex of 61, co-authored 156 publications receiving 13162 citations. Previous affiliations of Seulki Lee include Johns Hopkins University & National Institutes of Health.
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Journal ArticleDOI
Nanoparticle-based theranostic agents
Jin Xie,Seulki Lee,Xiaoyuan Chen +2 more
TL;DR: The current article will outline the progress along this line, organized by the category of the core materials, and focus on construction strategies and will discuss the challenges and opportunities associated with this emerging technology.
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Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease
Seung Pil Yun,Tae In Kam,Nikhil Panicker,SangMin Kim,Yumin Oh,Jong-Sung Park,Seung-Hwan Kwon,Yong Joo Park,Senthilkumar S. Karuppagounder,Hyejin Park,Sangjune Kim,Nayeon Oh,Nayoung Alice Kim,Saebom Lee,Saurav Brahmachari,Xiaobo Mao,Jun Hee Lee,Manoj Kumar,Daniel An,Sung Ung Kang,Yunjong Lee,Kang Choon Lee,Dong Hee Na,Dong-Hoon Kim,Sang Hun Lee,Viktor V. Roschke,Shane A. Liddelow,Zoltan Mari,Ben A. Barres,Valina L. Dawson,Seulki Lee,Ted M. Dawson,Han Seok Ko +32 more
TL;DR: It is found that NLY01 is a potent GLP1R agonist with favorable properties that is neuroprotective through the direct prevention of microglia-mediated conversion of astrocytes to an A1 neurotoxic phenotype and should be evaluated in the treatment of Parkinson’s disease and related neurologic disorders characterized by microglial activation.
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Polymeric nanomedicine for cancer therapy
TL;DR: The characteristics of cancer that provide nanodrug targeting opportunities are highlighted and rational approaches for future development of polymeric nanomedicines are discussed.
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PET/NIRF/MRI triple functional iron oxide nanoparticles.
Jin Xie,Kai Chen,Jing Huang,Jing Huang,Seulki Lee,Seulki Lee,Jinhua Wang,Jinhao Gao,Xingguo Li,Xiaoyuan Chen,Xiaoyuan Chen +10 more
TL;DR: Dopamine is utilized to modify the surface of IONPs, yielding nanoconjugates that can be easily encapsulated into human serum albumin (HSA) matrices (clinically utilized drug carriers), which is well-suited for dual encapsulation of IonPs and drug molecules.
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Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy.
Kyung Hyun Min,Kyeongsoon Park,Yoo Shin Kim,Sang Mun Bae,Seulki Lee,Hyung Gon Jo,Hyung Gon Jo,Rang Woon Park,In San Kim,Seo Young Jeong,Kwangmeyung Kim,Ick Chan Kwon +11 more
TL;DR: The delivery of CPT to tumor tissues at a high concentration, with the assistance of HGC nanoparticles, exerted a potent therapeutic effect and reveal the promising potential of H GC nanoparticles-encapsulated CPT as a stable and effective drug delivery system in cancer therapy.