Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment.
Jooho Park,Yongwhan Choi,Yongwhan Choi,Hyeyoun Chang,Hyeyoun Chang,Wooram Um,Ju Hee Ryu,Ick Chan Kwon,Ick Chan Kwon,Ick Chan Kwon +9 more
TLDR
Current attempts at overcoming the limitations of traditional EPR-dependent nanomedicine by incorporating supplementary strategies, such as additional molecular targeting, physical alteration, or physiological remodeling of the tumor microenvironment are focused on.Abstract:
The use of nanomedicine for cancer treatment takes advantage of its preferential accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The development of cancer nanomedicine has promised highly effective treatment options unprecedented by standard therapeutics. However, the therapeutic efficacy of passively targeted nanomedicine is not always satisfactory because it is largely influenced by the heterogeneity of the intensity of the EPR effect exhibited within a tumor, at different stages of a tumor, and among individual tumors. In addition, limited data on EPR effectiveness in human hinders further clinical translation of nanomedicine. This unsatisfactory therapeutic outcome in mice and humans necessitates novel approaches to improve the EPR effect. This review focuses on current attempts at overcoming the limitations of traditional EPR-dependent nanomedicine by incorporating supplementary strategies, such as additional molecular targeting, physical alteration, or physiological remodeling of the tumor microenvironment. This review will provide valuable insight to researchers who seek to overcome the limitations of relying on the EPR effect alone in cancer nanomedicine and go "beyond the EPR effect".read more
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The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy.
TL;DR: 24 research articles and reviews discussing different aspects of the EPR effect and cancer nanomedicine are collected, together providing a comprehensive and complete overview of the current state-of-the-art and future directions in tumor-targeted drug delivery.
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Design of liposomes as drug delivery system for therapeutic applications.
TL;DR: An overview of liposomes can be found in this article, where the main design aspects to obtain a successful liposomal formulation were addressed, following the techniques for liposome production and drug loading.
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Nanomedicines for Reactive Oxygen Species Mediated Approach: An Emerging Paradigm for Cancer Treatment.
TL;DR: The integration of nanomedicine and ROS-mediated therapy has emerged as the new paradigm in the treatment of cancer, based on promising proof-of-concept demonstrations in preclinical studies.
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Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors.
Sabrina Dallavalle,Vladimir Dobričić,Loretta Lazzarato,Elena Gazzano,Miguel Machuqueiro,Ilza Pajeva,Ivanka Tsakovska,Nace Zidar,Roberta Fruttero +8 more
TL;DR: Promising recent approaches that have been developed with the aim of circumventing or overcoming MDR are explored, including the pharmaco-modulation of acridine, the use of natural compounds as means to reverse MDR, and the conjugation of anticancer drugs with carriers that target specific tumor-cell components.
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Recent trends in protein and peptide-based biomaterials for advanced drug delivery.
TL;DR: Progress in engineering the architecture and biological functions of peptide-based biomaterials —naturally derived, chemically synthesized and recombinant— with a focus on the molecular features that modulate their structure-function relationships for drug delivery are discussed.
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Yasuhiro Matsumura,Hiroshi Maeda +1 more
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