I.C. Hume

TL;DR: These macromolecular produgs have the ability to concentrate drug in solid tumours, and with incorporation of targeting residues can promote organ-specific or tumour-specific uptake, and covalent conjugation markedly reduces all aspects of DOX-associated toxicity.

TL;DR: The conjugates tested were all less effective than free daunomycin, but they showed differential toxicity against L1210 depending on the aminoacid sequence of their drug-polymer linkage, and inclusion of fucosylamine-terminating side-chains into the HPMA copolymer structure increased the affinity of conjugate for the L12 10 cell membrane and resulted in increased toxicity.

TL;DR: Under certain experimental conditions polymer-DNM conjugates containing fucosylamine or galactosamine proved more active than conjugate without the carbohydrate moeity, and the mechanism of drug-conjugate action in vivo is at present unclear.

TL;DR: It was shown that the human hepatoma cell line HepG2 retains the galactose receptor, accumulating and processing the conjugate efficiently, and potential dose limiting toxicities of such drug conjugates could include cardio- or hepatotoxicity.

TL;DR: Slow releasing ADR conjugates containing tripeptide spacers were most effective in increasing animal lifespan and Cytotoxicity measured in vitro did not correlate with the rate of drug release seen during incubation with papain and tritosomes.