Len Seymour

TL;DR: The initial results of this retinal gene therapy trial are consistent with improved rod and cone function that overcome any negative effects of retinal detachment, and lend support to further assessment of gene therapy in the treatment of choroideremia and other diseases, such as age-related macular degeneration, for which intervention should ideally be applied before the onset ofretinal thinning.

TL;DR: Present knowledge of the biodistribution and cellular interactions of gene delivery systems are summarized and how improvements in gene delivery will be accomplished in the future are considered.

TL;DR: An increase in the bioavailability of adenovirus, coupled with substantial decreases in toxicity and unwanted transgene expression is an important step towards producing systemically available tumour-targeted viruses.

TL;DR: These macromolecular produgs have the ability to concentrate drug in solid tumours, and with incorporation of targeting residues can promote organ-specific or tumour-specific uptake, and covalent conjugation markedly reduces all aspects of DOX-associated toxicity.