Jiří Strohalm

TL;DR: The results suggest the “EPR effect” in solid tumor primarily arises from in the difference in clearance rate between the solid tumor and the normal tissues after initial penetration of the polymers into these tissues.

TL;DR: This paper describes the synthesis, physico-chemical characteristics and results of selected biological tests of conjugates of antibodies or proteins with poly(HPMA) or withpoly( HPMA) carriers of anti-cancer drug doxorubicin, designed for targeted cancer therapy.

TL;DR: The molecular weight-dependence of tumour capture of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers was studied in vivo using subcutaneous Sarcoma 180 or B16F10 melanoma models and the ratio (accumulation index, AI) of the AUC in tumour to A UC in skeletal muscle (a typical normal tissue) increasing from six to 12 with increasing copolymer molecular weight.

TL;DR: Attachment of adriamycin to N-(2-hydroxypropyl)methacrylamide copolymer considerably decreased its toxicity against haematopoietic precursors in bone marrow as measured by the in vivo colony-forming unit-spleen assay and its ability to inhibit [3H] thymidine incorporation by mouse splenocytes and human peripheral blood lymphocytes measured in vitro.

TL;DR: These macromolecular produgs have the ability to concentrate drug in solid tumours, and with incorporation of targeting residues can promote organ-specific or tumour-specific uptake, and covalent conjugation markedly reduces all aspects of DOX-associated toxicity.