I
I. MacIntyre
Researcher at Repatriation General Hospital
Publications - 11
Citations - 651
I. MacIntyre is an academic researcher from Repatriation General Hospital. The author has contributed to research in topics: Receptor & Breast cancer. The author has an hindex of 9, co-authored 11 publications receiving 648 citations.
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Journal ArticleDOI
1,25-dihydroxyvitamin-D-receptor in breast cancer cells.
TL;DR: A specific receptor for 1,25-dihydroxyvitamin D has been demonstrated in a cultured human breast cancer cell line, the first such demonstration in any cancer cell.
Journal Article
Calcitonin and 1,25-Dihydroxyvitamin D3 Receptors in Human Breast Cancer Cell Lines
David M. Findlay,V. P. Michelangeli,John A. Eisman,R. J. Frampton,Jane M. Moseley,I. MacIntyre,R. Whitehead,Thomas J. Martin +7 more
TL;DR: Breast cancer cell lines provide a useful source of 1,25-dihydroxyvitamin D3 receptors and their coexistence with a calcitonin receptor and biological response in some breast cancers offers the opportunity to investigate new aspects of breast cancer endocrinology.
Journal ArticleDOI
1,25-dihydroxyvitamin D3 specifically binds to a human breast cancer cell line (T47D) and stimulates growth.
TL;DR: The T47D human breast cancer cell line contains a specific binding protein for 1.25-(OH) 2 D 3, with 15000 sites per cell, and the Kd and sedimentation coefficient on sucrose gradients are the same as those reported for the 1,25-OH-2 D 3 receptor in other tissues.
Journal ArticleDOI
1,25-Dihydroxyvitamin D3 receptor in a cultured human breast cancer cell line (MCF 7 cells).
TL;DR: MCF 7 cells are shown to possess a receptor for 1,25-dihydroxyvitamin D 3 with a low capacity and high affinity and which sediments at 3.7S in sucrose density gradients are very similar to those found for the well characterised chicken intestinal 1, 25-(OH) 2 D receptor.
Journal ArticleDOI
Normal and malignant breast tissue is a target organ for 1,25-(0H)2 vitamin D3.
TL;DR: Results suggest that 1,25‐dihydroxyvitamin D3 may activate calcium transport in the malignant as well as in the normal lactating breast.