Journal ArticleDOI
1,25-dihydroxyvitamin-D-receptor in breast cancer cells.
TLDR
A specific receptor for 1,25-dihydroxyvitamin D has been demonstrated in a cultured human breast cancer cell line, the first such demonstration in any cancer cell.About:
This article is published in The Lancet.The article was published on 1979-12-29. It has received 151 citations till now. The article focuses on the topics: Breast cancer & CA15-3.read more
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Design of the Women's Health Initiative clinical trial and observational study
Garnet L. Anderson,S. Cummings,L. S. Freedman,C. Furberg,Maureen M. Henderson,Susan R. Johnson,L. Kuller,JoAnn E. Manson,A. Oberman,Ross L. Prentice,Jacques E. Rossouw,L. Finnegan,R. Hiatt,L. Pottern,J. McGowan,C. Clifford,B. Caan,V. Kipnis,B. Ettinger,S. Sidney,G. Bailey,Andrea Z. LaCroix,Anne McTiernan,Deborah J. Bowen,C. Chen,Barbara B. Cochrane,Julie R. Hunt,Alan R. Kristal,Brian J. Lund,Ruth E. Patterson,Jeffrey L. Probstfield,Lesley F. Tinker,Nicole Urban,Ching Yun Wang,Emily White,J. M. Kotchen,S. Shumaker,P. Rautaharju,F. Rautaharju,E. Stein,P. Laskarzewski,P. Steiner,K. Sagar,M. Nevitt,M. Dockrell,T. Fuerst,John H. Himes,M. Stevens,F. Cammarata,S. Lindenfelser,Bruce M. Psaty,D. Siscovick,W. Longstreth,S. Heckbert,S. Wassertheil-Smoller,W. Frishman,Judy Wylie-Rosett,D. Barad,R. Freeman,S. Miller,Jennifer Hays,R. Young,C. Crowley,M. A. DePoe,G. Burke,E. Paskett,L. Wagenknecht,R. Crouse,L. Parsons,T. Kotchen,E. Braunwald,J. Buring,C. Hennekens,J. M. Gaziano,Annlouise R. Assaf,R. C. Carleton,M. Miller,C. Wheeler,A. Hume,M. Pedersen,O. Strickland,M. Huber,V. Porter,Shirley A.A. Beresford,V. Taylor,N. Woods,J. Hsia,V. Barnabei,M. Bovun,Rowan T. Chlebowski,R. Detrano,A. Nelson,J. Heiner,S. Pushkin,B. Valanis,V. Stevens,E. Whitlock,N. Karanja,A. Clark +98 more
TL;DR: The rationale for the interventions being studied in each of the CT components and for the inclusion of the OS component is described, including a brief description of the scientific and logistic complexity of the WHI.
Journal ArticleDOI
The Role of Vitamin D in Cancer Prevention
Cedric F. Garland,Frank C. Garland,Edward D. Gorham,Martin Lipkin,Harold L. Newmark,Sharif B. Mohr,Michael F. Holick +6 more
TL;DR: The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.
Journal ArticleDOI
Nonclassic Actions of Vitamin D
TL;DR: The nonclassic actions of vitamin D are cell specific and provide a number of potential new clinical applications for 1,25(OH)(2)D(3) and its analogs, however, the use ofitamin D metabolites and analogs for these applications remains limited by the classic actions of Vitamin D leading to hypercalcemia and hypercalcuria.
Journal ArticleDOI
The vitamin D endocrine system: steroid metabolism, hormone receptors, and biological response (calcium binding proteins).
TL;DR: Vitamin D was first identified through the nutritional studies of Sir Edward Mellanby (243), which identified rickets as a disease state resulting from a deficiency of vitamin D, as well as through the biochemical/chemical studies of McCollum and co-workers (242), who demonstrated that there was more than one fat-soluble vitamin.
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Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation.
TL;DR: Vitamin D from sunlight exposure may be associated with low risk for fatal breast cancer, and differences in ultraviolet light reaching the United States population may account for the striking regional differences in breast cancer mortality.
References
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Journal ArticleDOI
A sensitive, precise, and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma☆
TL;DR: With this method, rachitic chick plasma, plasma from anephric patients, and plasma from patients suffering severe endstage renal failure show no detectable 1,25-dihydroxyvitamin D, while normal human values have been found to be 29 ± 2 pg/ml.
Journal ArticleDOI
Estrogen Receptor in a Human Cell Line (MCF-7) from Breast Carcinoma
TL;DR: A stable cell line derived by pleural effusion from a breast cancer patient has been demonstrated to contain significant amounts of 17β-estradiol receptor, which has a Kd equal to 2.5 nm, a sedimentation constant of 4.0 S, and a mechanism capable of transporting the 17 β-ESTradiol into the nucleus.
Journal ArticleDOI
Oestrogen-responsive human breast cancer in long term tissue culture.
Marc E. Lippman,Gail Bolan +1 more
TL;DR: The characterisation of several human breast cancer cell lines are reported, at least one of which shows marked dependence on oestrogens for growth, which seems to be similar in a variety of ways to that observed clinically in vivo.
Journal ArticleDOI
Direct resorption of bone by human breast cancer cells in vitro
Gabriel Eilon,Gregory R. Mundy +1 more
TL;DR: C cultured human breast cancer cells have the capacity to resorb directly in vitro, independently of osteoclast stimulation, and this shows that bone metastases occur frequency in patients with advanced malignancy.
Journal ArticleDOI
Specific progesterone receptors in human breast cancer
TL;DR: A synthetic progestin is used, R5020 (17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione), whose binding specificity is restricted to progesterone receptor, which is distinct from glucocorticoid receptor and CBG as determined by competition studies using dexamethasone and hydrocortisone.