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Iain R. Thompson
Researcher at University of London
Publications - 14
Citations - 773
Iain R. Thompson is an academic researcher from University of London. The author has contributed to research in topics: Receptor & Anterior pituitary. The author has an hindex of 8, co-authored 14 publications receiving 660 citations. Previous affiliations of Iain R. Thompson include Royal Veterinary College & Brigham and Women's Hospital.
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Journal ArticleDOI
Central precocious puberty caused by mutations in the imprinted gene MKRN3
Ana Paula Abreu,Andrew Dauber,Delanie B. Macedo,Sekoni D. Noel,Vinicius Nahime Brito,John C. Gill,Priscilla Cukier,Iain R. Thompson,Víctor M. Navarro,Priscila Gagliardi,Tânia Rodrigues,Cristiane Kochi,Carlos Alberto Longui,Dominique Beckers,Francis de Zegher,Luciana Ribeiro Montenegro,Berenice B. Mendonca,Rona S. Carroll,Joel N. Hirschhorn,Ana Claudia Latronico,Ursula B. Kaiser +20 more
TL;DR: Deficiency of MKRN3 causes central precocious puberty in humans, and all affected persons inherited the mutations from their fathers, a finding that indicates perfect segregation with the mode of inheritance expected for an imprinted gene.
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GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression
TL;DR: Current research efforts aim to discover the mechanisms responsible for the decoding of the GnRH pulse signal by the gonadotrope, which has the potential to lead to new therapies for patients with altered gonadotropic secretion, such as those with hypothalamic amenorrhea or polycystic ovarian syndrome.
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GnRH pulse frequency-dependent stimulation of FSHβ transcription is mediated via activation of PKA and CREB
TL;DR: Data indicate that a PKA-mediated signaling pathway mediates GnRH activation of CREB at low-pulse frequencies, playing a significant role in the decoding of the hypothalamic GnRH signal to result in frequency-dependent FSHβ activation.
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Substance P Regulates Puberty Onset and Fertility in the Female Mouse
Serap Simavli,Iain R. Thompson,Caroline A Maguire,John C. Gill,Rona S. Carroll,Andrew Wolfe,Ursula B. Kaiser,Víctor M. Navarro +7 more
TL;DR: Findings support a role for SP in the stimulation of gonadotropins before puberty, acting via Kiss1 neurons to stimulate GnRH release, and its involvement in the attainment of full reproductive capabilities in female mice.
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Nitric oxide/cGMP signalling mediates the cardioprotective action of adrenomedullin in reperfused myocardium
Shabaz A. Hamid,Shabaz A. Hamid,Matthias Totzeck,Christina Drexhage,Iain R. Thompson,Robert C. Fowkes,Tienush Rassaf,Gary F. Baxter +7 more
TL;DR: These data provide the first evidence that AM increases NO bioavailability in intact murine myocardium and confirm that the NO/sGC/cGMP pathway is central to the cytoprotective action of AM against ischaemia–reperfusion injury.