S
Sekoni D. Noel
Researcher at Brigham and Women's Hospital
Publications - 14
Citations - 1308
Sekoni D. Noel is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Precocious puberty & Isolated hypogonadotropic hypogonadism. The author has an hindex of 11, co-authored 14 publications receiving 1145 citations. Previous affiliations of Sekoni D. Noel include Harvard University.
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Journal ArticleDOI
Central precocious puberty caused by mutations in the imprinted gene MKRN3
Ana Paula Abreu,Andrew Dauber,Delanie B. Macedo,Sekoni D. Noel,Vinicius Nahime Brito,John C. Gill,Priscilla Cukier,Iain R. Thompson,Víctor M. Navarro,Priscila Gagliardi,Tânia Rodrigues,Cristiane Kochi,Carlos Alberto Longui,Dominique Beckers,Francis de Zegher,Luciana Ribeiro Montenegro,Berenice B. Mendonca,Rona S. Carroll,Joel N. Hirschhorn,Ana Claudia Latronico,Ursula B. Kaiser +20 more
TL;DR: Deficiency of MKRN3 causes central precocious puberty in humans, and all affected persons inherited the mutations from their fathers, a finding that indicates perfect segregation with the mode of inheritance expected for an imprinted gene.
Journal ArticleDOI
Mutations of the KISS1 gene in disorders of puberty
Leticia Ferreira Gontijo Silveira,Sekoni D. Noel,A. P. Silveira-Neto,Ana Paula Abreu,Vinicius Nahime Brito,Mario G. Santos,Suzy D.C. Bianco,Wendy Kuohung,Shuyun Xu,Mirta Gryngarten,M. E. Escobar,Ivo J.P. Arnhold,Berenice B. Mendonca,Ursula B. Kaiser,Ana Claudia Latronico +14 more
TL;DR: Two novel KISS1 missense mutations were identified in unrelated patients with idiopathic CPP, and the p.P74S variant was associated with higher kisspeptin resistance to degradation in comparison with the wild type, suggesting a role for this mutation in the precocious puberty phenotype.
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TAC3/TACR3 Mutations Reveal Preferential Activation of Gonadotropin-Releasing Hormone Release by Neurokinin B in Neonatal Life Followed by Reversal in Adulthood
Elena Gianetti,Cintia Tusset,Sekoni D. Noel,Margaret G. Au,Andrew A. Dwyer,Virginia A. Hughes,Ana Paula Abreu,Jessica Carroll,Ericka B. Trarbach,Leticia Ferreira Gontijo Silveira,Elaine Maria Frade Costa,Berenice B. Mendonca,Margaret de Castro,Adriana Lofrano,Janet E. Hall,Erol Bolu,Metin Ozata,Richard Quinton,John K. Amory,Susan E. Stewart,Wiebke Arlt,Trevor Cole,William F. Crowley,Ursula B. Kaiser,Ana Claudia Latronico,Stephanie B. Seminara +25 more
TL;DR: Although the neurokinin B pathway appears essential during early sexual development, its importance in sustaining the integrity of the hypothalamic-pituitary-gonadal axis appears attenuated over time.
Journal ArticleDOI
Increased Neurokinin B (Tac2) Expression in the Mouse Arcuate Nucleus Is an Early Marker of Pubertal Onset with Differential Sensitivity to Sex Steroid-Negative Feedback than Kiss1
John C. Gill,Víctor M. Navarro,Cecilia Kwong,Sekoni D. Noel,Cecilia Martin,Shuyun Xu,Donald K. Clifton,Rona S. Carroll,Robert A. Steiner,Ursula B. Kaiser +9 more
TL;DR: Results indicate that the expression of Tac2 and Tacr3 in the ARC are markers of pubertal activation but that increased NKB/NK3R signaling alone is insufficient to trigger the onset of puberty in the mouse.
Journal ArticleDOI
A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism
Milena Gurgel Teles,Ericka B. Trarbach,Sekoni D. Noel,Gil Guerra-Júnior,Alexander A. L. Jorge,Daiane Beneduzzi,Suzy D.C. Bianco,Abir Mukherjee,Abir Mukherjee,M. T. M. Baptista,Elaine Maria Frade Costa,M. de Castro,Berenice B. Mendonca,Ursula B. Kaiser,Ana Claudia Latronico +14 more
TL;DR: Loss-of-function mutations of KISS1R represents a rare cause of nIHH, and was absent in patients with CDP, and a novel homozygous splice acceptor site mutation is described in the familial form ofnIHH.