Iams Sg

TL;DR: Young male and female rats that become spontaneously hypertensive when they mature were gonadectomized at 30 days of age while they were still normotensive to demonstrate that estradiol was particularly effective in inhibiting the usual rise in blood pressure in intact (sham-operated) or gonadECTomized males and females.

TL;DR: An incremental change in circulating PRL, corticosterone, and aldosterone as early as 2 months of age, when blood pressure levels are beginning to rise, suggests that there may be some connection between the genetically programmed pathogenesis of the spontaneous hypertension and the progressively increasing (with age) sensitivity of the pituitary-adrenal axis to stress.

TL;DR: The results suggest that stimulation in C. briggsae is not the result of nutrient adsorption or phagocytosis, but rather due to the physical presence of particles.

TL;DR: It is suggested that the combined hormonal and metabolic alterations of diabetes and hypertension reinforced one another in these spontaneously hypertensive rats, leading to intense stimulation of the hypothalamic-pituitary-adrenal system, the exacerbation of those cardiovascular degenerative changes known to be associated with uncontrolled diabetes or hypertension, eventual impaired adrenocortical steroidogenesis, hypotension and death.

TL;DR: The observation of significantly decreased total body water and rates of evaporation at critical colonic temperatures suggested the possibility of a reduced ability for water mobilization for thermoregulatory purposes in hypertensive animals although it appeared that other factors affecting heat gain or loss were involved.