Journal ArticleDOI
Aldosterone, deoxycorticosterone, corticosterone, and prolactin changes during the lifespan of chronically and spontaneously hypertensive rats.
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TLDR
An incremental change in circulating PRL, corticosterone, and aldosterone as early as 2 months of age, when blood pressure levels are beginning to rise, suggests that there may be some connection between the genetically programmed pathogenesis of the spontaneous hypertension and the progressively increasing (with age) sensitivity of the pituitary-adrenal axis to stress.Abstract:
Male and female spontaneously hypertensive rats (SHR), which develop hypertension spontaneously with maturation, were autopsied at select time intervals from weaning to 28 months. Their blood pressure began to rise steeply at 4–5 weeks, reaching a zenith of 180–240 mm Hg after 4 months. Elevated blood pressures were maintained in both sexes. After 20 months, the male SHR began to die of myocardial infarction and hypotensive crisis. Heart and adrenal gland weight increased progressively not only during the phase of rapidly rising blood pressure but also during the period of plateaued but sustained high blood pressure. RIA of plasma levels of aldosterone, deoxycorticosterone, corticosterone, and PRL, under both quiescent and mildly stressful conditions, demonstrated that the pituitaryadrenal axis of SHR progressively increases its propensity to respond to stress with maturation. This capacity to respond to stress was maintained despite the severe high blood pressure and the attainment of relative old age, i...read more
Citations
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Journal ArticleDOI
Gender Differences in the Regulation of Blood Pressure
TL;DR: Findings in animal studies show that there is a blunting of the pressure-natriuresis relationship in male spontaneously hypertensive rats and in ovariectomized female spontaneously hypertension rats treated chronically with testosterone, suggesting that the loss of estrogens may be the only component involved in the higher blood pressure in women after menopause.
Journal ArticleDOI
Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats.
TL;DR: The hypothesis that male sex hormones contribute to the exacerbation of hypertension in SHR by reducing pressure-natriuresis is supported.
Journal ArticleDOI
Sex-specific differences in hypertension and associated cardiovascular disease
Katrina M Mirabito Colafella,Katrina M Mirabito Colafella,Katrina M Mirabito Colafella,Kate M. Denton,Kate M. Denton +4 more
TL;DR: Treatment strategies for hypertension and CVD that are tailored according to sex could lead to improved outcomes for affected patients.
Journal ArticleDOI
Comparison of the behavioural and endocrine response to forced swimming stress in five inbred strains of rats
TL;DR: There are important inter-strain differences in the forced swimming behaviour, with no differences between sexes; the various physiological indices of emotional reactivity follow a different trend and no warranted conclusion on differences in emotional reactivities should be based upon a single endocrine system or even only upon physiological measures.
Journal ArticleDOI
Gender Differences in Hypertension in Spontaneously Hypertensive Rats: Role of Androgens and Androgen Receptor
TL;DR: In this paper, the androgen receptor plays a role in hypertension in male SHR and whether testosterone alone can cause the hypertension or whether conversion to dihydrotestosterone is necessary.
References
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Journal Article
Development of a Strain of Spontaneously Hypertensive Rats
Kozo Okamoto,Kyuzo Aoki +1 more
TL;DR: The incidence of the spontaneous occurrence of hypertension increased, the development of hypertension occurred at younger ages from generation to generation, and all of the F3 to F6, rats developed spontaneous hypertension within 15 weeks of age.
Journal ArticleDOI
Development of a strain of spontaneously hypertensive rats.
Kozo Okamoto,Kyuzo Aoki +1 more
TL;DR: Okamoto-Aoki et al. as discussed by the authors found that the spontaneous occurrence of hypertension increased with age and the development of hypertension occurred at younger ages from generation to generation, increasing significantly above those of normotensive controls of the same age.
Journal ArticleDOI
Statistical quality control of radioimmunoassays.
TL;DR: An empirical quality control system is utilized in order to obtain estimates of the stability, precision and reproducibility of the radioimmunoassays and CPB assays, and permit the determination of valid estimates of confidence limits on potency estimates.
Journal ArticleDOI
A Radioimmunoassay for Plasma Aldosterone
TL;DR: The properties of antibodies to steroid-protein conjugates were investigated many years ago by Lieberman and his coworkers as discussed by the authors, who described a method, using antibodies to an aldosterone protein conjugate, to measure the purity of human plasma.
Related Papers (5)
Plasma Aldosterone and Corticosterone Responses to Adrenocorticotropin, Angiotensin, Potassium, and Stress in Spontaneously Hypertensive Rats
Retardation in the development of spontaneous hypertension in SH rats by gonadectomy.
S G Iams,B C Wexler +1 more