Ian D. Pavord

TL;DR: Sputum cytokine profiling can determine distinct and overlapping groups of subjects with asthma and COPD, supporting both the British and Dutch hypotheses and may contribute to improved patient classification to enable stratified medicine.

TL;DR: There was a reasonably close relationship between cough sensitivity and glottic-stop reflex sensitivity, indicating either that the cough reflex and the glOTTic- stop reflex share a common pathway or that subjects who have a chronic cough have a global abnormality of upper airway reflexes.

TL;DR: This phase 3, multinational, multicenter, randomized, double-blind, placebo-controlled, parallel-group trial in patients with persistent asthma who are receiving continuous treatment with inhaled corticosteroids plus one or two other asthma controller medicines examines the efficacy of dupilumab in this at-risk patient population.

TL;DR: In this article, a new monoclonal antibody targeting IgE, interleukin-4 and -13 is proposed for treating severe type 2 asthma, but new targets are needed.

TL;DR: Assessment of the diagnostic accuracy, clinical effectiveness and cost-effectiveness of the hand-held electrochemical devices NIOX MINO, NioX VERO, and NObreath for the diagnosis and management of asthma found varying levels of agreement between monitors, with better agreement at lower FeNO values.