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Ian F. Harrison
Researcher at University College London
Publications - 38
Citations - 1595
Ian F. Harrison is an academic researcher from University College London. The author has contributed to research in topics: Glymphatic system & Neurodegeneration. The author has an hindex of 18, co-authored 34 publications receiving 1048 citations. Previous affiliations of Ian F. Harrison include Imperial College London.
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Journal ArticleDOI
Epigenetic targeting of histone deacetylase: Therapeutic potential in Parkinson's disease?
Ian F. Harrison,David T. Dexter +1 more
TL;DR: Examining the evidence of the neuroprotective effects of numerous HDACIs in cellular and animal models of Parkinsonian cell death is examined, answering the question: does epigenetic targeting of histone deacetylases hold therapeutic potential in PD.
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Nuclear import of HIV‐1 intracellular reverse transcription complexes is mediated by importin 7.
TL;DR: This work has studied nuclear import of purified HIV‐1 RTCs in primary macrophages and found that importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the process.
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Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease
Niall Colgan,Niall Colgan,Bernard Siow,James M. O'Callaghan,Ian F. Harrison,Jack A. Wells,Holly E. Holmes,Ozama Ismail,Simon Richardson,Daniel C. Alexander,Emily C. Collins,Elizabeth M. C. Fisher,Ross A. Johnson,Adam J. Schwarz,Zeshan Ahmed,Michael J. O'Neill,Tracey K. Murray,Hui Zhang,Mark F. Lythgoe +18 more
TL;DR: This in vivo dMRI study demonstrates that N ODDI identifies potential tissue sources contributing to DTI indices and NODDI may provide greater specificity to pathology in Alzheimer's disease.
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Impaired glymphatic function and clearance of tau in an Alzheimer's disease model.
Ian F. Harrison,Ozama Ismail,Asif Machhada,Niall Colgan,Niall Colgan,Yolanda Ohene,Payam Nahavandi,Zeshan Ahmed,Alice Fisher,Soraya Meftah,Tracey K. Murray,Ole Petter Ottersen,Erlend A. Nagelhus,Michael J. O'Neill,Jack A. Wells,Mark F. Lythgoe +15 more
TL;DR: Modifying glymphatic flow by pharmacologically targeting aquaporin-4 alters tau clearance, suggesting therapeutic potential against tauopathies.
Journal ArticleDOI
Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI.
Ian F. Harrison,Bernard Siow,Bernard Siow,Aisha B Akilo,Phoebe G Evans,Ozama Ismail,Yolanda Ohene,Payam Nahavandi,David L. Thomas,Mark F. Lythgoe,Jack A. Wells +10 more
TL;DR: This work presents the first non-invasive technique for the assessment of glymphatic inflow by using an ultra-long echo time, low b-value, multi-direction diffusion weighted MRI sequence to assess perivascular fluid movement in the rat brain.