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Ian M. Jones
Researcher at University of Reading
Publications - 211
Citations - 8759
Ian M. Jones is an academic researcher from University of Reading. The author has contributed to research in topics: Virus & Fusion protein. The author has an hindex of 50, co-authored 203 publications receiving 7971 citations. Previous affiliations of Ian M. Jones include Yale University & University of Warwick.
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Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
Mansun Law,Toshiaki Maruyama,Jamie T. Lewis,Erick Giang,Alexander W. Tarr,Zania Stamataki,Pablo Gastaminza,Francis V. Chisari,Ian M. Jones,Robert I. Fox,Jonathan K. Ball,Jane A. McKeating,Norman M. Kneteman,Dennis R. Burton +13 more
TL;DR: The results provide evidence that broadly neutralizing antibodies to HCV protect against heterologous viral infection and suggest that a prophylactic vaccine against HCV may be achievable.
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Clustered Mutations in HIV-1 Gag Are Consistently Required for Escape from Hla-B27–Restricted Cytotoxic T Lymphocyte Responses
Anthony D. Kelleher,Chad Long,Edward C. Holmes,Rachel L. Allen,Jamie R F Wilson,Christopher P. Conlon,Cassy Workman,Sunil Shaunak,Kara Olson,Philip J. R. Goulder,Philip J. R. Goulder,Christian Brander,Graham S. Ogg,John S. Sullivan,Wayne B. Dyer,Ian M. Jones,Andrew J. McMichael,Sarah Rowland-Jones,Rodney E. Phillips +18 more
TL;DR: Phylogenetic analyses indicated that substitutions emerged under natural selection rather than by genetic drift or linkage for outgrowth of CTL escape viruses required high viral loads and additional, possibly compensatory, mutations in the gag protein.
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Consequences of manganese replacement of copper for prion protein function and proteinase resistance
David R. Brown,Farida Hafiz,Leslie L. Glasssmith,Boon Seng Wong,Ian M. Jones,Christine Clive,Stephen J. Haswell +6 more
TL;DR: Results show that it is possible to generate proteinase‐resistant PrP from cells and suggest a possible mechanism for the formation of the scrapie isoform of the PrP as generated in sporadic prion disease.
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The role of beta-hydroxyaspartate and adjacent carboxylate residues in the first EGF domain of human factor IX.
D. J. G. Rees,Ian M. Jones,Penny A. Handford,S. J. Walter,M. P. Esnouf,K. J. Smith,George G. Brownlee +6 more
TL;DR: It is suggested that Ca2+ binds to carboxylate ions in this domain and stabilizes a conformation necessary for the interaction of factor IXa with factor X, factor VIII and phospholipid in the next step of the clotting cascade.
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Sputnik V COVID-19 vaccine candidate appears safe and effective.
Ian M. Jones,Polly Roy +1 more